The cancer-immunity cycle provides a framework to understand the series of events that
generate anti-cancer immune responses. It emphasizes the iterative nature of the response …

Anticancer agents continue to dominate the list of newly approved drugs, approximately half
of which are immunotherapies. This trend illustrates the considerable promise of cancer …

Macrophages represent a key component of the tumor microenvironment (TME) and are
largely associated with poor prognosis. Therapeutic targeting of macrophages has …

Myeloid immune cells (MICs) are potent innate immune cells serving as first responders to
invading pathogens and internal changes to cellular homeostasis. Cancer is a stage of …

Immunometabolism is a burgeoning field of research that investigates how immune cells
harness nutrients to drive their growth and functions. Myeloid cells play a pivotal role in …

In religious philosophy, the concept of karma represents the effect of one's past and present
actions on one's future. Macrophages are highly plastic cells with myriad roles in health and …

Immunotherapies including adaptive immune checkpoint inhibitors (ICIs) and chimeric
antigen receptor (CAR) T cells, have developed the treatment of cancer in clinic, and most of …

Background To investigate the potential of Manuka honey (MH) as an immunomodulatory
agent in colorectal cancer (CRC) and dissect the underlying molecular and cellular …

Advances in immunotherapy have revolutionized cancer treatment, yet many patients do not
show clinical responses. While most immunotherapies target T cells, myeloid cells are the …

MDSCs are immature myeloid immune cells, which accumulate in models of liver cancer to
reduce effector immune cell activity, contribute to immune escape and treatment resistance …