Cross-species applicability of an adverse outcome pathway network for thyroid hormone system disruption

AC Haigis, L Vergauwen, CA LaLone… - Toxicological …, 2023 - academic.oup.com
Thyroid hormone system disrupting compounds are considered potential threats for human
and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone …

Biochemistry and physiology of zebrafish photoreceptors

J Zang, SCF Neuhauss - Pflügers Archiv-European Journal of Physiology, 2021 - Springer
All vertebrates share a canonical retina with light-sensitive photoreceptors in the outer
retina. These photoreceptors are of two kinds: rods and cones, adapted to low and bright …

Azole-Induced Color Vision Deficiency Associated with Thyroid Hormone Signaling: An Integrated In Vivo, In Vitro, and In Silico Study

ZF Chen, ZC Lin, SQ Lu, XF Chen… - Environmental …, 2022 - ACS Publications
Azoles that are used in pesticides, pharmaceuticals, and personal care products can have
toxic effects on fish. However, there is no information regarding azole-induced visual …

Partitioning of gene expression among zebrafish photoreceptor subtypes

Y Ogawa, JC Corbo - Scientific reports, 2021 - nature.com
Vertebrate photoreceptors are categorized into two broad classes, rods and cones,
responsible for dim-and bright-light vision, respectively. While many molecular features that …

Reversibility of Thyroid Hormone System–Disrupting Effects on Eye and Thyroid Follicle Development in Zebrafish (Danio rerio) Embryos

P Pannetier, R Poulsen, L Gölz… - Environmental …, 2023 - Wiley Online Library
Early vertebrate development is partially regulated by thyroid hormones (THs).
Environmental pollutants that interact with the TH system (TH system–disrupting chemicals …

AOP report: Thyroperoxidase inhibition leading to altered visual function in fish via altered retinal layer structure

L Gölz, L Baumann, P Pannetier… - Environmental …, 2022 - Wiley Online Library
Thyroid hormones (THs) are involved in the regulation of many important physiological and
developmental processes, including vertebrate eye development. Thyroid hormone system …

Critical review of the toxicity mechanisms of bisphenol F in zebrafish (Danio rerio): Knowledge gaps and future directions

B Dos Santos, E Ivantsova, AP Guzman, CJ Martyniuk - Chemosphere, 2022 - Elsevier
Replacement chemicals for bisphenol A, such as bisphenol F (BPF), are detected in aquatic
environments worldwide and can potentially exert negative effects on aquatic organisms …

The role of estrogen and thyroid hormones in zebrafish visual system function

A Cohen, J Popowitz, M Delbridge-Perry… - Frontiers in …, 2022 - frontiersin.org
Visual system development is a highly complex process involving coordination of
environmental cues, cell pathways, and integration of functional circuits. Consequently, a …

Effects of pollutant toxicity on the eyes of aquatic life monitored by visual dysfunction in zebrafish: A review

XF Chen, ZC Lin, Z Qi, Z Cai, ZF Chen - Environmental Chemistry Letters, 2023 - Springer
The eyes of aquatic organisms may be damaged by exposure to pollutants. Zebrafish is a
common laboratory model to study ocular toxicity, combining both fish and vertebrate …

Transcription factors underlying photoreceptor diversity

JM Angueyra, VP Kunze, LK Patak, H Kim, K Kindt… - Elife, 2023 - elifesciences.org
During development, retinal progenitors navigate a complex landscape of fate decisions to
generate the major cell classes necessary for proper vision. Transcriptional regulation is …