Among a litany of malignancies affecting the female reproductive tract, that of the ovary is the
most frequently fatal. Moreover, while the steady pace of scientific discovery has fuelled …

BACKGROUND Endometriosis is an often chronic, inflammatory gynaecologic condition
affecting 190 million women worldwide. Studies have reported an elevated cancer risk …

Background Low-grade serous carcinoma of the ovary or peritoneum is characterised by
MAPK pathway aberrations and its reduced sensitivity to chemotherapy relative to high …

Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage.
Experimental in vitro models that faithfully capture the hallmarks and tumor heterogeneity of …

Pharmacologic inhibition of PARP is the primary therapeutic strategy for BRCA mutant
ovarian cancer. However, most of patients carry wild-type BRCA1/2 with no significant …

Abstract Background Glucose-Regulated Protein 78 (GRP78) is a chaperone heat shock
protein that has been intensely studied in the last two decades. GRP78 is the master of the …

Abstract Treatment of high-grade serous ovarian cancer (HGSOC) remains challenging.
Although HGSOC can potentially be responsive to immunotherapy owing to endogenous …

Ovarian cancer is one of the most common gynecologic cancers and has the highest
mortality rate of any other cancer of the female reproductive system. Epithelial ovarian …

Abstract Purpose of Review Endometriosis is a disease of adolescents and reproductive-
aged women characterized by the presence of endometrial tissue outside the uterine cavity …

Epithelial ovarian cancer (EOC) is one of the cancers most influenced by hereditary factors.
A fourth to a fifth of unselected EOC patients carry pathogenic variants (PVs) in a number of …