More than two decades after the natural gene-silencing mechanism of RNA interference was
elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the …

Mitochondria are heterogeneous and highly dynamic organelles, playing critical roles in
adenosine triphosphate (ATP) synthesis, metabolic modulation, reactive oxygen species …

RNA interference (RNAi) provides researchers with a versatile means to modulate target
gene expression. The major forms of RNAi molecules, genome-derived microRNAs …

Gamma-aminobutyric acid (Gaba) is a non-proteinogenic amino acid that is widely present
in microorganisms, plants, and vertebrates. So far, Gaba is well known as a main inhibitory …

Kidney disease represents a serious global health problem. One of the main concerns is its
late diagnosis, only feasible in a progressed disease state. The lack of a clinical …

Cardiorenal syndromes have been categorized into 5 clinical subtypes based on which
organ is perceived to be the primary precipitant of the vicious and interrelated cycle of …

Over the past 15 years, elegant studies have demonstrated that in certain conditions,
programed cell death resembles necrosis and depends on a unique molecular pathway with …

Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the
expression of specific genes. RNA interference technology, using synthetic structurally well …

New biomarkers are being evaluated for their ability to advance the management of patients
with heart failure. Despite a large pool of interesting candidate biomarkers, besides …

The manifestation of acute kidney injury (AKI) is associated with poor patient outcomes, with
treatment options limited to hydration or renal replacement therapies. The onset of AKI is …