Tetrameric assembly of channel subunits in the endoplasmic reticulum (ER) is essential for
surface expression and function of K+ channels, but the molecular mechanism underlying …

The acute heart rate response to exercise, ie, heart rate increase during and heart rate
recovery after exercise, has often been associated with all-cause and cardiovascular …

Psychiatric disorders represent a significant burden in our societies. Despite the convincing
evidence pointing at gene and gene-environment interaction contributions, the role of …

Potassium channels function in cellular tasks as ubiquitous as the setting of resting
potentials (Katz, 1966), and as specific as defining the interspike intervals of endogenously …

Caenorhabditis elegans regulates egg laying by alternating between an inactive phase and
a serotonin-triggered active phase. We found that the conserved ERG [ether-a-go-go (EAG) …

Torsades de pointes (TdP) is a potentially lethal cardiac arrhythmia that can occur as an
unwanted adverse effect of various pharmacological therapies. Before a drug is approved …

Background Government agencies have defined a need to reduce, refine or replace current
mammalian-based bioassays with testing methods that use alternative species. Invertebrate …

We summarize recent advances in the clinical genetics of hypercholesterolemia,
hypertrophic cardiomyopathy (HCM), and lethal arrhythmia, all of which are monogenic …

Anthropogenic micropollutants and transformation products (TPs) negatively affect aquatic
ecosystems and water resources. Wastewater treatment plants (WWTP) represent major …

The Caenorhabditis elegans male must integrate various environmental cues to ensure
proper execution of mating. One step of male mating, the insertion of the male copulatory …