The HERG (human ether-à-go-go-related gene) protein, which underlies the cardiac
repolarizing current I Kr, is the unintended target for many pharmaceutical agents …

Growing evidence suggests that drugs interact with diverse molecular targets mediating both
therapeutic and toxic effects. Prediction of these complex interactions from chemical …

Voltage-gated potassium channels (Kv channels) are the major determinants of cellular
repolarization in excitable cells-they open in response to depolarization and facilitate …

To explore other arsenic derivatives with anticancer effects and fewer adverse effects,
realgar bioleaching solution (RBS) has been found to be a viable approach. Here we used …

Aims Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease mainly caused
by desmosome gene mutations. The genetic culprit, however, remains elusive in∼ 50% of …

The human ether-a-go-go–related gene (hERG) encodes a voltage-gated potassium
channel that controls repolarization of cardiac action potentials. Accumulating evidence …

Human ether‐a‐go‐go‐related gene (HERG) encodes the rapid, outwardly rectifying K+
current IKr that is critical for repolarization of the cardiac action potential. Congenital HERG …

The acquired long QT syndrome (aLQTS) is frequently associated with extrinsic and intrinsic
risk factors including therapeutic agents that inadvertently inhibit the KCNH2 K+ channel that …

Background: Long-QT syndrome (LQTS) is characterized by QT prolongation and increased
risk for syncope, seizures, and sudden cardiac death. The majority of LQTS stems from …

由人类ether-à-go-go 相关基因(HERG) 编码的钾离子通道在人类生理, 病理过程中扮演着十分
重要的角色. 在心肌细胞中, HERG 钾通道影响心脏动作电位的复极过程, 是绝大多数能引起心肌 …