Recently, Willuhn et al. reported that cocaine use and even non-substance-related addictive
behavior increases as dopaminergic function is reduced. Chronic cocaine exposure has …

Reward deficiency syndrome (RDS) was first proposed by Kenneth Blum in 1995 to provide
a clinically relevant and predictive term for conditions involving deficits in mesocorticolimbic …

Previous PET imaging studies have demonstrated mixed findings regarding dopamine
D2/D3 receptor availability in obese relative to nonobese humans. Nonspecific D2/D3 …

During the last decade, there has been a worldwide increase in popularity and abuse of
synthetic cathinones. Common ingredients of the so‐called bath salts include mephedrone …

Background Following the first association between the dopamine D2 receptor gene
polymorphism and severe alcoholism, there has been an explosion of research reports in …

Drug-related cues are potent triggers for relapse in people with cocaine dependence.
Dopamine (DA) release within a limbic network of striatum, amygdala and hippocampus has …

Dopaminergic reward dysfunction in addictive behaviors is well supported in the literature.
There is evidence that alterations in synchronous neural activity between brain regions …

Background and Purpose: In many neurologic diagnoses, significant interindividual
variability exists in the outcomes of rehabilitation. One factor that may impact response to …

The purpose of this study was to examine reward-related genetic risk for addictive behaviors
in a healthy community sample (n= 217) of men and women. We tested a mediation model …

Psychoactive drug use occurs in essentially all human societies. A range of disciplines
contribute to our understanding of the influence of drugs upon the human world. For …