Autophagy is a lysosome-dependent intracellular degradation system required for various
physiological processes and can be dysregulated in human disease. To understand its …

Intracellular pathogens have evolved various efficient molecular armaments to subvert
innate defenses. Cellular ubiquitination, a normal physiological process to maintain …

Autophagy is a common name for a number of catabolic processes, which keep the cellular
homeostasis by removing damaged and dysfunctional intracellular components. Impairment …

Ubiquitination, the post-translational modification essential for various intracellular
processes, is implicated in multiple aspects of autophagy, the major lysosome/vacuole …

Selective autophagy of mitochondria, mitophagy, is linked to mitochondrial quality control
and as such is critical to a healthy organism. We have used a CRISPR/Cas9 approach to …

Certain inhibitor of apoptosis (IAP) family members are sentinel proteins that prevent
untimely cell death by inhibiting caspases. Antagonists, including second mitochondria …

Combinatorial CRISPR-Cas screens have advanced the mapping of genetic interactions,
but their experimental scale limits the number of targetable gene combinations. Here, we …

Alterations in autophagy and the ubiquitin proteasome system (UPS) are commonly
implicated in protein aggregation and toxicity which manifest in a number of neurological …

Cellular senescence is a hallmark of aging and has been linked to age-related diseases.
Age-related macular degeneration (AMD), the most common aging-related retinal disease …

Autophagy and apoptosis are functionally distinct mechanisms for cytoplasmic and cellular
turnover. While these two pathways are distinct, they can also regulate each other, and …