Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …

The Hippo signalling pathway has emerged as a major player in many aspects of liver
biology, such as development, cell fate determination, homeostatic function and …

Cancer-associated fibroblasts (CAF) are a poorly characterized cell population in the context
of liver cancer. Our study investigates CAF functions in intrahepatic cholangiocarcinoma …

Single-cell RNA sequencing (scRNA-seq) enables specific profiling of cell populations at
single-cell resolution. The osteoimmunology microenvironment in the occurrence and …

The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently
activated during the growth and progression of many solid tumors, including lung, colorectal …

The Hippo signaling pathway and its two downstream effectors, the YAP and TAZ
transcriptional coactivators, are drivers of tumor growth in experimental models. Studying …

The Hippo signaling pathway, also known as the Salvador− Warts− Hippo pathway, is a
regulator of organ size. The pathway takes its name from the Drosophila protein kinase …

Biliary epithelial cells (BECs) form bile ducts in the liver and are facultative liver stem cells
that establish a ductular reaction (DR) to support liver regeneration following injury. Liver …

LGR4/5 receptors and their cognate RSPO ligands potentiate Wnt/β-catenin signalling and
promote proliferation and tissue homeostasis in epithelial stem cell compartments. In the …

Ferroptosis is a new form of regulated cell death resulting from the accumulation of lipid-
reactive oxygen species. A growing number of studies indicate ferroptosis as an important …