Osteoarthritis is the most common joint disorder and a major cause of disability with a major
socio-economic impact. In these circumstances is very important to understand its …

Osteoarthritis (OA) is the most common chronic musculoskeletal disorder. It can affect any
joint and is the most frequent single cause of disability in older adults. OA is a progressive …

Osteoarthritis (OA) is a joint disease affecting millions of patients worldwide. During OA
onset and progression, the articular cartilage is destroyed, but the underlying complex …

Despite four decades of research in intra-articular drug delivery systems (DDS) and two
decades of advances in disease-modifying osteoarthritis drugs (DMOADs), there is still no …

Targeting chondrocyte dynamics is a strategy for slowing osteoarthritis progression during
aging. We describe a stable-isotope method using in vivo deuterium oxide labeling and …

Background Cell-based therapies such as autologous chondrocyte implantation are
promising therapeutic approaches to treat cartilage defects to prevent further cartilage …

Prior study has shown that Ageratum conyzoides L. extract that containing quercetin has
been proved to prevent inflammation and proteoglycan degradation by inhibiting tumor …

Objective To investigate the role of integrin α1β1 in the progression of post-traumatic
osteoarthritis (PTOA), and elucidate the contribution of epidermal growth factor receptor …

Diacerein (DCN) was obtained by diacetylation of an anthraquinone derivative rhein and
was approved by FDA in 2008, in the treatment of osteoarthritis due to its inhibitory effect on …

Articular cartilage is a hyaline cartilage 2–4 mm thick. It is composed of 95% of dense
extracellular matrix (ECM) and 5% of highly specialized cells called chondrocytes. Because …