[HTML][HTML] The Bioavailability of Drugs—The Current State of Knowledge

M Stielow, A Witczyńska, N Kubryń, Ł Fijałkowski… - Molecules, 2023 - mdpi.com
Drug bioavailability is a crucial aspect of pharmacology, affecting the effectiveness of drug
therapy. Understanding how drugs are absorbed, distributed, metabolized, and eliminated in …

Carbamazepine therapy after bariatric surgery: eight sleeve gastrectomy cases and review of the literature

D Porat, N Margolin, O Lavon, A Dahan - Obesity Surgery, 2022 - Springer
Bariatric surgery modifies the anatomy and physiology of the gastrointestinal tract.
Carbamazepine (CBZ) is an anticonvulsant with multiple neuropsychiatric indications. Given …

Selective COX-2 inhibitors after bariatric surgery: Celecoxib, etoricoxib and etodolac post-bariatric solubility/dissolution and pharmacokinetics

D Porat, O Dukhno, M Partook-Maccabi… - International Journal of …, 2023 - Elsevier
Anatomical/physiological gastrointestinal changes after bariatric surgery may influence the
fate of orally administered drugs. Since non-selective NSAIDs are not well-tolerated post …

Antiallergic treatment of bariatric patients: Potentially hampered solubility/dissolution and bioavailability of loratadine, but not desloratadine, post-bariatric surgery

D Porat, O Dukhno, E Vainer, S Cvijic… - Molecular …, 2022 - ACS Publications
Gastrointestinal anatomical/physiological changes after bariatric surgery influence variables
affecting the fate of drugs after ingestion, and medication management of these patients …

[HTML][HTML] Managing the unpredictable: mechanistic analysis and clinical recommendations for lamotrigine treatment after bariatric surgery

D Porat, C Azran, H Kais, A Dahan - Journal of Clinical Medicine, 2021 - mdpi.com
Bariatric surgery may alter the absorption and overall bioavailability of oral drugs.
Lamotrigine is a major antiepileptic and mood stabilizer, that its use after bariatric surgery …

[HTML][HTML] The Complexity of Bariatric Patient's Pharmacotherapy: Sildenafil Biopharmaceutics and Pharmacokinetics before vs. after Gastric Sleeve/Bypass

D Porat, O Dukhno, S Cvijić, A Dahan - Pharmaceutics, 2023 - mdpi.com
Postbariatric altered gastrointestinal (GI) anatomy/physiology may significantly harm oral
drug absorption and overall bioavailability. In this work, sildenafil, the first …

Metformin Hydrochloride Loaded Mucoadhesive Microspheres and Nanoparticles for Anti-Hyperglycemic and Anticancer Effects Using Factorial Experimental Design

AA Kotha, SU Ahmad, I Dewan… - Drug design …, 2023 - Taylor & Francis
Background Metformin hydrochloride (HCl) microspheres and nanoparticles were
formulated to enhance bioavailability and minimize side effects through sustained action …

[PDF][PDF] Avaliação metabólica de portadores de obesidade grave após 10 anos de Bypass Gástrico em Y-de-Roux

CC BARROS - repositorio.unicamp.br
RESUMO O Glucagon-like peptide-1 (GLP-1) é um hormônio amplamente estudado no
seguimento pós-operatório de bypass gástrico em Y-de-Roux (BGYR) devido à sua …