Vaccination is one of medicine's greatest achievements; however, its full potential is
hampered by considerable variation in efficacy across populations and geographical …

Macrophages are innate immune cells with essential roles in host defense, inflammation,
immune regulation and repair. During infection with multicellular helminth parasites …

Abstract Background RTS, S/AS01 has been recommended by WHO for widespread
implementation in medium to high malaria transmission settings. Previous analyses have …

Vaccines are one of the most successful medical inventions to enable the eradication or
control of common and fatal diseases. Environmental exposure of hosts, including helminth …

Strongyloides stercoralis is a soil transmitted helminth endemic to tropical and subtropical
areas that can persist for decades in immunocompetent human hosts as a chronic …

Despite the many efforts of researchers around the world, there is currently no effective
vaccine for malaria. Numerous studies have been developed to find vaccine antigens that …

Introduction Recurrent parasitic infections may influence the immune response to vaccines.
In the Partnership for Research on Ebola VACcinations extended follow-UP and clinical …

Helminth parasites infect more than a quarter of the human population and inflict significant
changes to the immunological status of their hosts. Several human studies report impaired …

Introduction Schistosomiasis is a public health issue of concern in Gabon, with the disease
being reported from all regions of the country. The topic has been of interest for the local …

Controlled human infection studies have contributed significantly to the understanding of
pathogeneses and treatment of infectious diseases. In malaria, deliberately infecting …