One of the major mechanisms of drug-induced liver injury includes mitochondrial
perturbation and dysfunction. This is not a surprise, given that mitochondria are essential …

Amiodarone, a bi-iodinated benzofuran derivative, is, because of its high effectiveness, one
of the most widely used antiarrhythmic agents. However, adverse effects, especially …

Amiodarone is an iodinated benzofuran derivative, a highly lipophilic drug with
unpredictable pharmacokinetics. Although originally classified as a class III agent due to its …

The generation of reactive metabolites from therapeutic agents is one of the major
mechanisms of drug-induced liver injury (DILI). In order to evaluate metabolism-related …

Abstract Three-dimensional (3D) cell spheroid models combined with mass spectrometry
imaging (MSI) enables innovative investigation of in vivo-like biological processes under …

Background Atrial fibrillation (AF) is the most common arrhythmia and its management in
cirrhosis can be challenging due to the altered hepatic metabolism of medications and …

The role played by oxidative stress in amiodarone-induced mitochondrial toxicity is debated.
Dronedarone shows pharmacological properties similar to those of amiodarone but several …

In recent years, humanity has been confronted with a global pandemic due to coronavirus
disease 2019 (COVID-19), which has caused an unprecedented health and economic crisis …

Abstract Amiodarone [2-butyl-3-(3′, 5′-diiodo-4'α-diethylaminoethoxybenzoyl)-
benzofuran](AMD), a class III antiarrhythmic drug, is known to cause idiosyncratic …

Drug-induced mitochondrial toxicity is rapidly gaining recognition within the pharmaceutical
industry as a contributor to compound attrition and post-market drug withdrawals. This article …