The nuclear factor κB (NF-κB) signaling cascade has been implicating in a broad range of
biological processes, including inflammation, cell proliferation, differentiation, and apoptosis …

Simple Summary Since its first description 35 years ago, the transcription factor NF-κB
(nuclear factor κ-light-chain-enhancer of activated B cells) has been shown to be a key …

Background Inflammaging represents an accepted concept where the immune system shifts
to a low-grade chronic pro-inflammatory state without overt infection upon aging. In the CNS …

Ras homolog (Rho)-associated kinases (ROCKs) belong to the serine-threonine kinase
family, which plays a pivotal role in regulating the damage, survival, axon guidance, and …

Remyelination therapies, which are currently under development, have a great potential to
delay, prevent or even reverse disability in multiple sclerosis patients. Several models are …

Demyelinating disorders are among the most common and debilitating diseases in
neurology. Canavan disease (CD) is a lethal demyelinating disease caused by mutation of …

The transcription factor nuclear factor κB (NF-κB) plays major roles in inflammatory diseases
through regulation of inflammation and cell viability. Multiple sclerosis (MS) is a chronic …

Neuronal disorders are associated with a profound loss of mitochondrial functions caused
by various stress conditions, such as oxidative and metabolic stress, protein folding or import …

Failure of central nervous system projection neurons to spontaneously regenerate long-
distance axons underlies irreversibility of white matter pathologies. A barrier to axonal …

Protein kinase R (PKR)-like endoplasmic reticulum (ER) kinase (PERK) is one of the three
major sensors in the unfolded protein response (UPR). The UPR is involved in the …