Quinoline and quinazoline alkaloids, two important classes of N‐based heterocyclic
compounds, have attracted tremendous attention from researchers worldwide since the 19th …

Protein kinase C (PKC) comprises a family of serine/threonine kinases that are involved in
the transduction of signals for cell proliferation, differentiation, apoptosis and angiogenesis …

Aberrations in cell cycle progression occur in the majority of human malignancies. The main
pathway affected is the retinoblastoma (Rb) pathway. The tumor suppressor gene Rb is an …

Triple negative breast cancers, which are defined by lack of expression of estrogen,
progesterone, or HER2 receptors, represent approximately 15% of all breast cancers …

Mutations in TP53 lead to a defective G1 checkpoint and the dependence on checkpoint
kinase 1 (Chk1) for G2 or S phase arrest in response to DNA damage. In preclinical studies …

Background The covalent linkage between DNA and the active site tyrosine of
topoisomerase I can be stabilized by chemotherapeutic agents, adjacent DNA lesions, or …

Protein kinase C (PKC) is a family of serine/threonine kinases that is involved in the
transduction of signals for cell proliferation and differentiation. The important role of PKC in …

Camptothecin (CPT) is a potent DNA Topoisomerase I inhibitor with anti-tumor activity in
hematological and solid tumors. However, it did not reach clinical use because of its poor …

Abstract Background: 7-Hydroxystaurosporine (UCN-01) inhibits serine–threonine kinases
including the Ca 2+ and phospholipid-dependent protein kinase C (PKC), CDKs 2, 4, 6, Chk …

Simple Summary Approximately 2,261,419 new cases of breast cancer (BC) and 684,996
BC-related deaths are estimated to occur in 2020 globally. New individualized therapeutic …