Prodrugs of non-steroidal anti-inflammatory drugs (NSAIDs): a long march towards synthesis of safer NSAIDs

S Sehajpal, DN Prasad… - Mini reviews in medicinal …, 2018 - ingentaconnect.com
As a therapeutic group, non-steroidal anti-inflammatory drugs (NSAIDs) are among the most
widely used, prescribed and over the counter (OTC) medications for the treatment of …

[HTML][HTML] Anti-ulcer activity of essential oil constituents

FA Oliveira, LN Andrade, ÉBV De Sousa, DP De Sousa - Molecules, 2014 - mdpi.com
Essential oils have attracted considerable worldwide attention over the last few decades.
These natural products have wide-ranging pharmacological activities and biotechnological …

Molecular Docking and In Silico Cogitation Validate Mefenamic Acid Prodrugs as Human Cyclooxygenase-2 Inhibitor

K Shah, S Mujwar, JK Gupta… - Assay and drug …, 2019 - liebertpub.com
In silico molecular docking is an efficient technique for drug design that predicts the
optimized orientation of the ligand against a specific drug target. This is a cost-effective and …

Signed, sealed, delivered: conjugate and prodrug strategies as targeted delivery vectors for antibiotics

AV Cheng, WM Wuest - ACS infectious diseases, 2019 - ACS Publications
Innate and developed resistance mechanisms of bacteria to antibiotics are obstacles in the
design of novel drugs. However, antibacterial prodrugs and conjugates have shown promise …

[HTML][HTML] Prodrugs of NSAIDs: A review

K Shah, JK Gupta, NS Chauhan… - The open medicinal …, 2017 - ncbi.nlm.nih.gov
Results: As an outcome the search for a prodrug or mutual prodrug with reduced toxicity has
continued during recent years. This present review emphasizes the common help to revamp …

Novel ketoprofen–antioxidants mutual codrugs as safer nonsteroidal anti‐inflammatory drugs: Synthesis, kinetic and pharmacological evaluation

S Sehajpal, DN Prasad, RK Singh - Archiv der Pharmazie, 2019 - Wiley Online Library
Ketoprofen belongs to one of the most common nonsteroidal anti‐inflammatory drugs
(NSAIDs) but its clinical usefulness has been restricted due to the high incidence of …

An insight into prodrug strategy for the treatment of Alzheimer's disease

NV Bhilare, VS Marulkar, D Kumar, VK Chatap… - Medicinal Chemistry …, 2022 - Springer
Alzheimer's disease (AD) is the leading cause of dementia worldwide. With 35 million
people over 60 suffering from dementia, new treatments for AD are immediately needed. In …

Lead optimization on conventional non‐steroidal anti‐inflammatory drugs: an approach to reduce gastrointestinal toxicity

T Narsinghani, R Sharma - Chemical biology & drug design, 2014 - Wiley Online Library
Non‐steroidal anti‐inflammatory drugs are among the most widely used therapeutics,
primarily for the treatment for pain and inflammation. Prostaglandins mediate a number of …

An insight of non-steroidal anti-inflammatory drug mefenamic acid: A review

S Rajat, MM Kumar, PA Kumar… - GSC Biological and …, 2019 - gsconlinepress.com
This review focuses on the design, synthesis and pharmacological effects of non-steroidal
anti-inflammatory (NSAIDs) mefenamic acid which is an anthranilic acid derivative …

Preparation and biological evaluation of metronidazole derivatives with monoterpenes and eugenol

MM Bkhaitan, M Alarjah, AZ Mirza… - Chemical Biology & …, 2018 - Wiley Online Library
Two series of metronidazole derivatives (ester derivatives and ether derivatives) were
prepared reacting metronidazole and its acetic acid oxidized form with menthol, thymol …