Prodrugs of non-steroidal anti-inflammatory drugs (NSAIDs): a long march towards synthesis of safer NSAIDs
S Sehajpal, DN Prasad… - Mini reviews in medicinal …, 2018 - ingentaconnect.com
As a therapeutic group, non-steroidal anti-inflammatory drugs (NSAIDs) are among the most
widely used, prescribed and over the counter (OTC) medications for the treatment of …
widely used, prescribed and over the counter (OTC) medications for the treatment of …
[HTML][HTML] Anti-ulcer activity of essential oil constituents
FA Oliveira, LN Andrade, ÉBV De Sousa, DP De Sousa - Molecules, 2014 - mdpi.com
Essential oils have attracted considerable worldwide attention over the last few decades.
These natural products have wide-ranging pharmacological activities and biotechnological …
These natural products have wide-ranging pharmacological activities and biotechnological …
Molecular Docking and In Silico Cogitation Validate Mefenamic Acid Prodrugs as Human Cyclooxygenase-2 Inhibitor
In silico molecular docking is an efficient technique for drug design that predicts the
optimized orientation of the ligand against a specific drug target. This is a cost-effective and …
optimized orientation of the ligand against a specific drug target. This is a cost-effective and …
Signed, sealed, delivered: conjugate and prodrug strategies as targeted delivery vectors for antibiotics
AV Cheng, WM Wuest - ACS infectious diseases, 2019 - ACS Publications
Innate and developed resistance mechanisms of bacteria to antibiotics are obstacles in the
design of novel drugs. However, antibacterial prodrugs and conjugates have shown promise …
design of novel drugs. However, antibacterial prodrugs and conjugates have shown promise …
[HTML][HTML] Prodrugs of NSAIDs: A review
Results: As an outcome the search for a prodrug or mutual prodrug with reduced toxicity has
continued during recent years. This present review emphasizes the common help to revamp …
continued during recent years. This present review emphasizes the common help to revamp …
Novel ketoprofen–antioxidants mutual codrugs as safer nonsteroidal anti‐inflammatory drugs: Synthesis, kinetic and pharmacological evaluation
S Sehajpal, DN Prasad, RK Singh - Archiv der Pharmazie, 2019 - Wiley Online Library
Ketoprofen belongs to one of the most common nonsteroidal anti‐inflammatory drugs
(NSAIDs) but its clinical usefulness has been restricted due to the high incidence of …
(NSAIDs) but its clinical usefulness has been restricted due to the high incidence of …
An insight into prodrug strategy for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is the leading cause of dementia worldwide. With 35 million
people over 60 suffering from dementia, new treatments for AD are immediately needed. In …
people over 60 suffering from dementia, new treatments for AD are immediately needed. In …
Lead optimization on conventional non‐steroidal anti‐inflammatory drugs: an approach to reduce gastrointestinal toxicity
T Narsinghani, R Sharma - Chemical biology & drug design, 2014 - Wiley Online Library
Non‐steroidal anti‐inflammatory drugs are among the most widely used therapeutics,
primarily for the treatment for pain and inflammation. Prostaglandins mediate a number of …
primarily for the treatment for pain and inflammation. Prostaglandins mediate a number of …
An insight of non-steroidal anti-inflammatory drug mefenamic acid: A review
S Rajat, MM Kumar, PA Kumar… - GSC Biological and …, 2019 - gsconlinepress.com
This review focuses on the design, synthesis and pharmacological effects of non-steroidal
anti-inflammatory (NSAIDs) mefenamic acid which is an anthranilic acid derivative …
anti-inflammatory (NSAIDs) mefenamic acid which is an anthranilic acid derivative …
Preparation and biological evaluation of metronidazole derivatives with monoterpenes and eugenol
Two series of metronidazole derivatives (ester derivatives and ether derivatives) were
prepared reacting metronidazole and its acetic acid oxidized form with menthol, thymol …
prepared reacting metronidazole and its acetic acid oxidized form with menthol, thymol …