Obstructive sleep apnea (OSA) is a disorder characterized by chronic intermittent hypoxia
and sleep fragmentation due to recurring airway collapse during sleep. It is highly prevalent …

Obstructive sleep apnoea (OSA) is recognised to be a potent risk factor for hypertension,
coronary heart disease, strokes and heart failure with a reduced ejection fraction. However …

Background Obstructive sleep apnoea (OSA) causes intermittent hypoxia that in turn
induces endothelial dysfunction and atherosclerosis progression. We hypothesised that VE …

Obstructive sleep apnoea is characterized by chronic intermittent hypoxaemia and is
independently associated with an increased risk of metabolic comorbidities (eg type II …

Sleep-disordered breathing (SDB) is highly prevalent in adults and leads to significant
cardiovascular and neurologic sequelae. Intermittent hypoxia during sleep is a direct …

Abstract Study Objectives Obstructive sleep apnea (OSA) is a chronic condition
characterized by intermittent hypoxia (IH) that is implicated in an increased risk of …

Aging is accompanied by changes in the quantity and quality of sleep. Obstructive sleep
apnea (OSA) is also more prevalent in the older population. Although severe OSA has been …

Hypoxic-ischemic brain injury poses a significant threat to the neural niche within the central
nervous system. In response to this pathological process, microglia, as innate immune cells …

Intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), is associated with
cardiovascular and metabolic dysfunction. However, the mechanisms underlying these …

Objective Obstructive sleep apnea (OSA) is a major risk factor for cardiovascular mortality.
Apnea-induced chronic intermittent hypoxia (CIH) is a primary pathophysiological …