PCR in Forensic Science: A Critical Review

C McDonald, D Taylor, A Linacre - Genes, 2024 - mdpi.com
The polymerase chain reaction (PCR) has played a fundamental role in our understanding
of the world, and has applications across a broad range of disciplines. The introduction of …

Inhibition mechanisms of hemoglobin, immunoglobulin G, and whole blood in digital and real-time PCR

M Sidstedt, J Hedman, EL Romsos, L Waitara… - Analytical and …, 2018 - Springer
Blood samples are widely used for PCR-based DNA analysis in fields such as diagnosis of
infectious diseases, cancer diagnostics, and forensic genetics. In this study, the mechanisms …

[HTML][HTML] Development of the VISAGE enhanced tool and statistical models for epigenetic age estimation in blood, buccal cells and bones

A Woźniak, A Heidegger, D Piniewska-Róg… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
DNA methylation is known as a biomarker for age with applications in forensics. Here we
describe the VISAGE (VISible Attributes through GEnomics) Consortium's enhanced tool for …

[HTML][HTML] Individual shedder status and the origin of touch DNA

L Jansson, M Swensson, E Gifvars, R Hedell… - Forensic Science …, 2022 - Elsevier
Due to improved laboratory techniques, touched surfaces and items are increasingly
employed as sources of forensic DNA evidence. This has urged a need to better understand …

[图书][B] Forensic biology: identification and DNA analysis of biological evidence

R Li - 2008 - taylorfrancis.com
Designed as an accessible introduction to basic scientific principles and their application in
professional practice, Forensic Biology provides a concise overview of the field. Focusing …

Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans

D Pesta, F Hoppel, C Macek… - American Journal …, 2011 - journals.physiology.org
Endurance and strength training are established as distinct exercise modalities, increasing
either mitochondrial density or myofibrillar units. Recent research, however, suggests that …

Overcoming inhibition in real-time diagnostic PCR

J Hedman, P Rådström - PCR detection of microbial pathogens, 2013 - Springer
PCR is an important and powerful tool in several fields, including clinical diagnostics, food
analysis, and forensic analysis. In theory, PCR enables the detection of one single cell or …

[HTML][HTML] Humic substances cause fluorescence inhibition in real-time polymerase chain reaction

M Sidstedt, L Jansson, E Nilsson, L Noppa… - Analytical …, 2015 - Elsevier
Real-time polymerase chain reaction (qPCR) is the cornerstone of DNA analysis, enabling
detection and quantification of minute nucleic acid amounts. However, PCR-based analysis …

Evaluation of the Illumina ForenSeq™ DNA Signature Prep Kit–MPS forensic application for the MiSeq FGx™ benchtop sequencer

C Xavier, W Parson - Forensic Science International: Genetics, 2017 - Elsevier
Abstract Massively Parallel (Next Generation) Sequencing (MPS) technologies have
recently been proven useful and successful in typing various markers relevant in forensic …

Mystery solved: the identification of the two missing Romanov children using DNA analysis

MD Coble, OM Loreille, MJ Wadhams, SM Edson… - PloS one, 2009 - journals.plos.org
One of the greatest mysteries for most of the twentieth century was the fate of the Romanov
family, the last Russian monarchy. Following the abdication of Tsar Nicholas II, he and his …