Pathological features and prognostication in colorectal cancer

K Chen, G Collins, H Wang, JWT Toh - Current Oncology, 2021 - mdpi.com
The prognostication of colorectal cancer (CRC) has traditionally relied on staging as defined
by the Union for International Cancer Control (UICC) and American Joint Committee on …

[HTML][HTML] Different treatment strategies and molecular features between right-sided and left-sided colon cancers

H Shen, J Yang, Q Huang, MJ Jiang… - World journal of …, 2015 - ncbi.nlm.nih.gov
The colon is derived from the embryological midgut and hindgut separately, with the right
colon and left colon having different features with regards to both anatomical and …

Comparison of oncological outcomes of right-sided colon cancer versus left-sided colon cancer after curative resection: which side is better outcome?

DR Lim, JK Kuk, T Kim, EJ Shin - Medicine, 2017 - journals.lww.com
Results: On average, RCC exhibited a more advanced N stage, increased tumor size, more
frequently poorly differentiated tumors, more harvested lymph nodes, and more positivity of …

Microsatellite instability and survival in stage II colorectal cancer: a systematic review and meta-analysis

F Petrelli, M Ghidini, M Cabiddu, E Pezzica… - Anticancer …, 2019 - ar.iiarjournals.org
Background/Aim: About 15-20% of colorectal cancers (CRCs) have deficiency in a mismatch
repair (MMR) protein. MMR has a high level of microsatellite instability (MSI-H). We have …

Distinguishable prognostic signatures of left-and right-sided colon cancer: a study based on sequencing data

L Liang, J Zeng, X Qin, J Chen, D Luo… - Cellular Physiology and …, 2018 - karger.com
Abstract Background/Aims: Left-and right-sided colon cancers are considered to be two
different diseases and have altered outcomes. However, specific molecules to predict the …

[HTML][HTML] Comparison of microsatellite status detection methods in colorectal carcinoma

ML Chen, JY Chen, J Hu, Q Chen, LX Yu… - … Journal of Clinical …, 2018 - ncbi.nlm.nih.gov
There are two commonly accepted methods for detecting microsatellite status. One is to
detect amplified microsatellite loci by polymerase chain reaction (PCR) and the other is to …

Rate of dissemination and prognosis in early and advanced stage colorectal cancer based on microsatellite instability status: systematic review and meta-analysis

JWT Toh, K Phan, F Reza, P Chapuis… - International Journal of …, 2021 - Springer
Introduction For the past two decades, microsatellite instability (MSI) has been reported as a
robust clinical biomarker associated with survival advantage attributed to its immunogenicity …

Microsatellite instability is associated with reduced disease specific survival in stage III colon cancer

HM Mohan, E Ryan, I Balasubramanian… - European Journal of …, 2016 - Elsevier
Background Up to 15% of colorectal cancers exhibit microsatellite instability (MSI), where
errors in replication go unchecked due to defects in the mismatch repair system. This study …

Small RNA expression from viruses, bacteria and human miRNAs in colon cancer tissue and its association with microsatellite instability and tumor location

R Mjelle, W Sjursen, L Thommesen, P Sætrom, E Hofsli - BMC cancer, 2019 - Springer
Background MicroRNAs (miRNA) and other small RNAs are frequently dysregulated in
cancer and are promising biomarkers for colon cancer. Here we profile human, virus and …

[HTML][HTML] Downregulation of acetyl-CoA synthetase 2 is a metabolic hallmark of tumor progression and aggressiveness in colorectal carcinoma

JM Bae, JH Kim, HJ Oh, HE Park, TH Lee, NY Cho… - Modern Pathology, 2017 - Elsevier
Acetyl-CoA synthetase-2 is an emerging key enzyme for cancer metabolism, which supplies
acetyl-CoA for tumor cells by capturing acetate as a carbon source under stressed …