HypoxamiRs and cancer: from biology to targeted therapy
Significance: Hypoxia is a hallmark of the tumor microenvironment and represents a major
source of failure in cancer therapy. Recent Advances: Recent work has generated extensive …
source of failure in cancer therapy. Recent Advances: Recent work has generated extensive …
Implications of in vitro research on the effect of radiotherapy and chemotherapy under hypoxic conditions
A Wouters, B Pauwels, F Lardon… - The oncologist, 2007 - academic.oup.com
Learning Objectives After completing this course, the reader will be able to: Argue why
hypoxic regions in solid tumors often contain viable cells that are intrinsically more resistant …
hypoxic regions in solid tumors often contain viable cells that are intrinsically more resistant …
hsa‐miR‐210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer
BACKGROUND: Hypoxia is an important mechanism of treatment resistance in head and
neck squamous cell carcinoma (HNSCC). MicroRNAs are short noncoding RNAs that …
neck squamous cell carcinoma (HNSCC). MicroRNAs are short noncoding RNAs that …
Cellular radiosensitivity of soft tissue sarcoma
RL Haas, BGJ Floot, AN Scholten… - Radiation …, 2021 - meridian.allenpress.com
Currently, all soft tissue sarcomas (STS) are irradiated by the same regimen, disregarding
possible subtype-specific radiosensitivities. To gain further insight, cellular radiosensitivity …
possible subtype-specific radiosensitivities. To gain further insight, cellular radiosensitivity …
Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1α functional interplay
F Marampon, GL Gravina, BM Zani… - International …, 2014 - spandidos-publications.com
The molecular mechanisms by which glioblastoma multiforme (GBM) refracts and becomes
resistant to radiotherapy treatment remains largely unknown. This radioresistance is partly …
resistant to radiotherapy treatment remains largely unknown. This radioresistance is partly …
Expression patterns of the hypoxia-related genes osteopontin, CA9, erythropoietin, VEGF and HIF-1α in human glioma in vitro and in vivo
HM Said, C Hagemann, A Staab, J Stojic… - Radiotherapy and …, 2007 - Elsevier
BACKGROUND AND PURPOSE: To identify molecular markers of tumor hypoxia and
potential therapeutic targets in glioblastoma (GBM), we investigated the hypoxia-related …
potential therapeutic targets in glioblastoma (GBM), we investigated the hypoxia-related …
Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells
A Staab, J Loeffler, HM Said, D Diehlmann, A Katzer… - BMC cancer, 2007 - Springer
Abstract Background Hypoxia-inducible factor-1 (HIF-1) overexpression has been linked to
tumor progression and poor prognosis. We investigated whether targeting of HIF-1 using …
tumor progression and poor prognosis. We investigated whether targeting of HIF-1 using …
Detection and specific targeting of hypoxic regions within solid tumors: current preclinical and clinical strategies
Poor oxygenation of solid tumors is a major indicator of adverse prognosis after standard
treatment, eg radiotherapy. This observation founded on intratumoral pO2 electrode …
treatment, eg radiotherapy. This observation founded on intratumoral pO2 electrode …
Tumor oxygenation status as a prognostic marker
C Menon, DL Fraker - Cancer letters, 2005 - Elsevier
Tumor oxygenation status is an independent prognostic indicator in cancer because it
influences tumor progression and treatment outcome. Its quantitative value is determined by …
influences tumor progression and treatment outcome. Its quantitative value is determined by …
A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1α
Hypoxia-inducible factor-1, HIF1, transcriptionally activates over 200 genes vital for cell
homeostasis and angiogenesis. We developed a computational model to gain a detailed …
homeostasis and angiogenesis. We developed a computational model to gain a detailed …