A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …

Mitochondria play a key role in maintaining energy homeostasis in metabolic tissues,
including adipose tissues. The two main types of adipose tissues are the white adipose …

World population has been continuously increasing and progressively aging. Aging is
characterized by a complex and intraindividual process associated with nine major cellular …

Mitochondria play a key role in energy metabolism in many tissues, including cardiac and
skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be …

A causal role for mitochondrial DNA (mtDNA) mutagenesis in mammalian aging is
supported by recent studies demonstrating that the mtDNA mutator mouse, harboring a …

The air that we breathe contains nearly 21% oxygen, most of which is utilized by
mitochondria during respiration. While we cannot live without it, it was perceived as a bane …

The G protein–coupled receptor 84 (GPR84), a medium-chain fatty acid receptor, has
garnered attention because of its potential involvement in a range of metabolic conditions …

Major depressive disorder (MDD) has been linked to mitochondrial defects, which could
manifest in mitochondrial DNA (mtDNA) polymorphisms or mutations. Additionally, copy …

Mitochondria regulate critical components of cellular function via ATP production, reactive
oxygen species production, Ca2+ handling and apoptotic signaling. Two classical methods …

The burden of heart failure (HF) in terms of health care expenditures, hospitalizations, and
mortality is substantial and growing. The failing heart has been described as “energy …