Neurotransmitters are released by synaptic vesicle exocytosis at the active zone of a
presynaptic nerve terminal. In this review, I discuss the molecular composition and function …

The neuromuscular junction is the chemical synapse between motor neurons and skeletal
muscle fibers. It is designed to reliably convert the action potential from the presynaptic …

Variants of UNC13A, a critical gene for synapse function, increase the risk of amyotrophic
lateral sclerosis and frontotemporal dementia,–, two related neurodegenerative diseases …

The neurotransmitter dopamine (DA) controls multiple behaviors and is perturbed in several
major brain diseases. DA is released from large populations of specialized structures called …

Amyotrophic lateral sclerosis (ALS) is a devastating, uniformly lethal degenerative disorder
of motor neurons that overlaps clinically with frontotemporal dementia (FTD). Investigations …

Vitamin D and its metabolites have pleomorphic roles in both nervous system health and
disease. Animal models have been paramount in contributing to our knowledge and …

Genetic discoveries in ALS have a significant impact on deciphering molecular mechanisms
of motor neuron degeneration. The identification of SOD1 as the first genetic cause of ALS …

We conducted a genome-wide association study among 2,323 individuals with sporadic
amyotrophic lateral sclerosis (ALS) and 9,013 control subjects and evaluated all SNPs with …

Diacylglycerol (DAG) has unique functions as a basic component of membranes, an
intermediate in lipid metabolism and a key element in lipid-mediated signaling. In …

The exocytosis of neurotransmitter-filled synaptic vesicles is under tight temporal and spatial
control in presynaptic nerve terminals. The fusion of synaptic vesicles is restricted to a …