Anti-trypanosomatid drug discovery: progress and challenges
Leishmaniasis (visceral and cutaneous), Chagas disease and human African
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …
Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei
NP Crilly, MR Mugnier - PLoS pathogens, 2021 - journals.plos.org
Trypanosoma brucei is a protozoan parasite that causes human and animal African
trypanosomiases (HAT and AAT). In the mammalian host, the parasite lives entirely …
trypanosomiases (HAT and AAT). In the mammalian host, the parasite lives entirely …
Adipocyte lipolysis protects mice against Trypanosoma brucei infection
Trypanosoma brucei causes African trypanosomiasis, colonizing adipose tissue and
inducing weight loss. Here we investigated the molecular mechanisms responsible for …
inducing weight loss. Here we investigated the molecular mechanisms responsible for …
γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection
JF Quintana, MC Sinton, P Chandrasegaran… - Nature …, 2023 - nature.com
African trypanosomes colonise the skin to ensure parasite transmission. However, how the
skin responds to trypanosome infection remains unresolved. Here, we investigate the local …
skin responds to trypanosome infection remains unresolved. Here, we investigate the local …
Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts
LJ Morrison, PC Steketee, MD Tettey, KR Matthews - Virulence, 2023 - Taylor & Francis
African trypanosomes are vector-borne protozoa, which cause significant human and animal
disease across sub-Saharan Africa, and animal disease across Asia and South America. In …
disease across sub-Saharan Africa, and animal disease across Asia and South America. In …
A review on the diagnosis of animal trypanosomoses
This review focuses on the most reliable and up-to-date methods for diagnosing
trypanosomoses, a group of diseases of wild and domestic mammals, caused by …
trypanosomoses, a group of diseases of wild and domestic mammals, caused by …
Induced transient immune tolerance in ticks and vertebrate host: a keystone of tick-borne diseases?
N Boulanger, S Wikel - Frontiers in immunology, 2021 - frontiersin.org
Ticks and tick transmitted infectious agents are increasing global public health threats due to
increasing abundance, expanding geographic ranges of vectors and pathogens, and …
increasing abundance, expanding geographic ranges of vectors and pathogens, and …
Prevalence of blood and skin trypanosomes in domestic and wild fauna from two sleeping sickness foci in Southern Cameroon
EMK Magang, RMN Kamga, J Telleria… - PLoS Neglected …, 2023 - journals.plos.org
Although studies on African Trypanosomiases revealed a variety of trypanosome species in
the blood of various animal taxa, animal reservoirs of Trypanosoma brucei gambiense and …
the blood of various animal taxa, animal reservoirs of Trypanosoma brucei gambiense and …
[HTML][HTML] SHERLOCK4HAT: A CRISPR-based tool kit for diagnosis of Human African Trypanosomiasis
N Sima, A Dujeancourt-Henry, BL Perlaza… - …, 2022 - thelancet.com
Background To achieve elimination of Human African Trypanosomiasis (HAT) caused by
Trypanosoma brucei gambiense (gHAT), the development of highly sensitive diagnostics is …
Trypanosoma brucei gambiense (gHAT), the development of highly sensitive diagnostics is …
Passive surveillance of human African trypanosomiasis in Côte d'Ivoire: Understanding prevalence, clinical symptoms and signs, and diagnostic test characteristics
Background Little is known about the diagnostic performance of rapid diagnostic tests
(RDTs) for passive screening of human African trypanosomiasis (HAT) in Côte d'Ivoire. We …
(RDTs) for passive screening of human African trypanosomiasis (HAT) in Côte d'Ivoire. We …