Treatment with the flavonoid 7, 8-Dihydroxyflavone: A promising strategy for a constellation of body and brain disorders
M Emili, S Guidi, B Uguagliati, A Giacomini… - Critical Reviews in …, 2022 - Taylor & Francis
Flavonoids have long been known to exert benefits in various health problems. Among
them, the BDNF mimetic 7, 8-Dihydroxyflavone (7, 8-DHF) is emerging as a potential …
them, the BDNF mimetic 7, 8-Dihydroxyflavone (7, 8-DHF) is emerging as a potential …
Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression
E Bouvier, F Brouillard, J Molet, D Claverie… - Molecular …, 2017 - nature.com
Stressful life events produce a state of vulnerability to depression in some individuals. The
mechanisms that contribute to vulnerability to depression remain poorly understood. A rat …
mechanisms that contribute to vulnerability to depression remain poorly understood. A rat …
7, 8-Dihydroxyflavone as a pro-neurotrophic treatment for neurodevelopmental disorders
Neurodevelopmental disorders are a group of conditions that arises from impairments of the
central nervous system during its development. The causes of the various disorders are …
central nervous system during its development. The causes of the various disorders are …
Myricetin suppresses oxidative stress-induced cell damage via both direct and indirect antioxidant action
ZH Wang, KA Kang, R Zhang, MJ Piao, SH Jo… - Environmental …, 2010 - Elsevier
We evaluated the cytoprotective effect of myricetin on oxidative stress damaged cells by
assessment of the scavenging effect of reactive oxygen species (ROS) and the activities of …
assessment of the scavenging effect of reactive oxygen species (ROS) and the activities of …
Protective effects of 7, 8-dihydroxyflavone on retinal ganglion and RGC-5 cells against excitotoxic and oxidative stress
VK Gupta, Y You, JC Li, A Klistorner… - Journal of Molecular …, 2013 - Springer
A preferential loss of retinal ganglion cells (RGCs) is observed in glaucoma and optic
neuritis. Loss of tropomyosin-related kinase receptor B (TrkB)-mediated signaling has been …
neuritis. Loss of tropomyosin-related kinase receptor B (TrkB)-mediated signaling has been …
Brain-derived neurotrophic factor mimetic, 7, 8-dihydroxyflavone, protects against myocardial ischemia by rebalancing optic atrophy 1 processing
Z Wang, S Wang, Q Shao, P Li, Y Sun, L Luo… - Free Radical Biology …, 2019 - Elsevier
Brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) pathway is
associated with ischemic heart diseases (IHD). 7, 8-dihydroxyflavone (7, 8-DHF), BDNF …
associated with ischemic heart diseases (IHD). 7, 8-dihydroxyflavone (7, 8-DHF), BDNF …
Antioxidant action of 7, 8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity
X Han, S Zhu, B Wang, L Chen, R Li, W Yao… - Neurochemistry …, 2014 - Elsevier
Oxidative stress-induced neuronal death plays a pivotal role in pathogenesis of
neurodegenerative disorders. Recently, 7, 8-dihydroxyflavone (7, 8-DHF) has been shown …
neurodegenerative disorders. Recently, 7, 8-dihydroxyflavone (7, 8-DHF) has been shown …
Activation of cardiac TrkB receptor by its small molecular agonist 7, 8-dihydroxyflavone inhibits doxorubicin-induced cardiotoxicity via enhancing mitochondrial …
J Zhao, J Du, Y Pan, T Chen, L Zhao, Y Zhu… - Free Radical Biology …, 2019 - Elsevier
Brain-derived neurotrophic factor (BDNF)/tropomyosin-related receptor kinase B (TrkB)
pathway has been revealed as a novel therapeutic target for several neurological diseases …
pathway has been revealed as a novel therapeutic target for several neurological diseases …
7, 8-Dihydroxiflavone maintains retinal functionality and protects various types of RGCs in adult rats with optic nerve transection
A Gallego-Ortega, B Vidal-Villegas… - International Journal of …, 2021 - mdpi.com
To analyze the neuroprotective effects of 7, 8-Dihydroxyflavone (DHF) in vivo and ex vivo,
adult albino Sprague-Dawley rats were given a left intraorbital optic nerve transection (IONT) …
adult albino Sprague-Dawley rats were given a left intraorbital optic nerve transection (IONT) …
Carnosic acid nanoparticles suppress liver ischemia/reperfusion injury by inhibition of ROS, Caspases and NF-κB signaling pathway in mice
H Li, JJ Sun, GY Chen, WW Wang, ZT Xie… - Biomedicine & …, 2016 - Elsevier
Living donor liver transplantation (LDLT) requires ischemia/reperfusion (I/R), which can lead
to early graft injury. However, the detailed molecular mechanism of I/R injury remains …
to early graft injury. However, the detailed molecular mechanism of I/R injury remains …