Development of ADHD: Etiology, heterogeneity, and early life course
Attention-deficit/hyperactivity disorder (ADHD) represents a powerful entry point for
developmental approaches to psychopathology due to its substantial role in early …
developmental approaches to psychopathology due to its substantial role in early …
[HTML][HTML] The dynamic landscape of open chromatin during human cortical neurogenesis
Non-coding regions comprise most of the human genome and harbor a significant fraction of
risk alleles for neuropsychiatric diseases, yet their functions remain poorly defined. We …
risk alleles for neuropsychiatric diseases, yet their functions remain poorly defined. We …
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
W Van Rheenen, RAA Van Der Spek, MK Bakker… - Nature …, 2021 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk
of one in 350 people and an unmet need for disease-modifying therapies. We conducted a …
of one in 350 people and an unmet need for disease-modifying therapies. We conducted a …
[HTML][HTML] Comparing within-and between-family polygenic score prediction
Polygenic scores are a popular tool for prediction of complex traits. However, prediction
estimates in samples of unrelated participants can include effects of population stratification …
estimates in samples of unrelated participants can include effects of population stratification …
[HTML][HTML] Trastorno por déficit de atención e hiperactividad (TDAH) en niños escolarizados de 6 a 17 años
LJ Llanos Lizcano, DJ García Ruiz… - Pediatría Atención …, 2019 - SciELO Espana
Objetivo: se buscó determinar la prevalencia del trastorno por déficit de atención e
hiperactividad (TDAH) en niños de entre 6 a 17 años escolarizados en Barranquilla, para …
hiperactividad (TDAH) en niños de entre 6 a 17 años escolarizados en Barranquilla, para …
Research review: A meta‐analysis of the international prevalence and comorbidity of mental disorders in children between 1 and 7 years
M Vasileva, RK Graf, T Reinelt… - Journal of Child …, 2021 - Wiley Online Library
Background Children younger than 7 years can develop mental disorders that might
manifest differently than in older children or adolescents. However, little is known about the …
manifest differently than in older children or adolescents. However, little is known about the …
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease
Genome-wide association studies have discovered hundreds of loci associated with
complex brain disorders, but it remains unclear in which cell types these loci are active. Here …
complex brain disorders, but it remains unclear in which cell types these loci are active. Here …
Exploring the genetic overlap between twelve psychiatric disorders
The widespread comorbidity among psychiatric disorders demonstrated in epidemiological
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …
Validity and utility of hierarchical taxonomy of psychopathology (HiTOP): II. Externalizing superspectrum
The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical effort to address
limitations of traditional mental disorder diagnoses. These include arbitrary boundaries …
limitations of traditional mental disorder diagnoses. These include arbitrary boundaries …
SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits
Local genetic correlation quantifies the genetic similarity of complex traits in specific
genomic regions. However, accurate estimation of local genetic correlation remains …
genomic regions. However, accurate estimation of local genetic correlation remains …