BackgroundAttention-deficit hyperactivity disorder (ADHD) is associated with later
depression and there is considerable genetic overlap between them. This study investigated …

There is mounting evidence that seemingly diverse psychiatric disorders share genetic
etiology, but the biological substrates mediating this overlap are not well characterized. Here …

Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a
heritability of 40–60%. A notable part of this heritability remains unexplained, and large …

Evidence from model organisms and clinical genetics suggests coordination between the
developing brain and face, but the role of this link in common genetic variation remains …

While neurodevelopmental disorders (NDDs) are highly heritable, several environmental
risk factors have also been suggested. However, the role of familial confounding is unclear …

Human DNA polymorphisms vary across geographic regions, with the most commonly
observed variation reflecting distant ancestry differences. Here we investigate the …

Tissue-specific regulatory regions harbor substantial genetic risk for disease. Because brain
development is a critical epoch for neuropsychiatric disease susceptibility, we characterized …

Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens …

Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations,
but associations between neurobiological mechanisms and macroscale connectomics …

Single-cell RNA sequencing (scRNA-seq) provides unique insights into the pathology and
cellular origin of disease. We introduce single-cell disease relevance score (scDRS), an …