[HTML][HTML] Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver
K Begriche, J Massart, MA Robin… - Journal of …, 2011 - Elsevier
Numerous investigations have shown that mitochondrial dysfunction is a major mechanism
of drug-induced liver injury, which involves the parent drug or a reactive metabolite …
of drug-induced liver injury, which involves the parent drug or a reactive metabolite …
Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
B Fromenty, D Pessayre - Pharmacology & therapeutics, 1995 - Elsevier
Severe and prolonged impairment of mitochondrial β-oxidation leads to microvesicular
steatosis, and, in severe forms, to liver failure, coma and death. Impairment of mitochondrial …
steatosis, and, in severe forms, to liver failure, coma and death. Impairment of mitochondrial …
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
TA Tummino, VV Rezelj, B Fischer, A Fischer… - Science, 2021 - science.org
Repurposing drugs as treatments for COVID-19, the disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has drawn much attention. Beginning …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has drawn much attention. Beginning …
Secondary causes of nonalcoholic fatty liver disease
JM Kneeman, J Misdraji… - Therapeutic advances in …, 2012 - journals.sagepub.com
Nonalcoholic fatty liver disease (NAFLD) is becoming the most common cause of chronic
liver disease in the developing world, found in 17-30% of the population in Western …
liver disease in the developing world, found in 17-30% of the population in Western …
Central role of mitochondria in drug-induced liver injury
D Pessayre, B Fromenty, A Berson… - Drug metabolism …, 2012 - Taylor & Francis
A frequent mechanism for drug-induced liver injury (DILI) is the formation of reactive
metabolites that trigger hepatitis through direct toxicity or immune reactions. Both events …
metabolites that trigger hepatitis through direct toxicity or immune reactions. Both events …
Histological patterns in drug-induced liver disease
R Ramachandran, S Kakar - Journal of clinical pathology, 2009 - jcp.bmj.com
The diagnosis of drug-induced liver injury (DILI) is a challenging problem, often confounded
by incomplete clinical information and the difficulty of eliciting exposure to herbal products …
by incomplete clinical information and the difficulty of eliciting exposure to herbal products …
[HTML][HTML] Drug-induced phospholipidosis
N Anderson, J Borlak - FEBS letters, 2006 - Elsevier
Drug-induced phospholipidosis is characterized by intracellular accumulation of
phospholipids with lamellar bodies, most likely from an impaired phospholipid metabolism of …
phospholipids with lamellar bodies, most likely from an impaired phospholipid metabolism of …
Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes
A Berson, V De Beco, P Lettéron, MA Robin, C Moreau… - Gastroenterology, 1998 - Elsevier
Background & Aims: 4, 4'-Diethylaminoethoxyhexestrol (DEAEH), amiodarone, and
perhexiline cause steatohepatitis in humans. The mechanisms of these effects are unknown …
perhexiline cause steatohepatitis in humans. The mechanisms of these effects are unknown …
The role of amiodarone in contemporary management of complex cardiac arrhythmias
Amiodarone is an iodinated benzofuran derivative, a highly lipophilic drug with
unpredictable pharmacokinetics. Although originally classified as a class III agent due to its …
unpredictable pharmacokinetics. Although originally classified as a class III agent due to its …
Impaired mitochondrial function in microvesicular steatosis effects of drugs, ethanol, hormones and cytokines
B Fromenty, D Pessayre - Journal of hepatology, 1997 - Elsevier
Microvesicular steatosis occurs in conditions characterized by severe impairment of the
mitochondrial β-oxidation process, due to genetic and/or acquired causes. Drugs and some …
mitochondrial β-oxidation process, due to genetic and/or acquired causes. Drugs and some …