The pharmacokinetics and the pharmacodynamics of cannabinoids

CJ Lucas, P Galettis, J Schneider - British journal of clinical …, 2018 - Wiley Online Library
There is increasing interest in the use of cannabinoids for disease and symptom
management, but limited information available regarding their pharmacokinetics and …

Cannabis sativa L. Bioactive Compounds and Their Protective Role in Oxidative Stress and Inflammation

DM Kopustinskiene, R Masteikova, R Lazauskas… - Antioxidants, 2022 - mdpi.com
Cannabis (Cannabis sativa L.) plants from the family Cannabidaceae have been used since
ancient times, to produce fibers, oil, and for medicinal purposes. Psychoactive delta-9 …

Adverse health effects of marijuana use

ND Volkow, RD Baler, WM Compton… - New England Journal …, 2014 - Mass Medical Soc
As marijuana use becomes legal in some states, the dominant public opinion is that
marijuana is a harmless source of mood alteration. Although the harms associated with …

A new ESI-LC/MS approach for comprehensive metabolic profiling of phytocannabinoids in Cannabis

P Berman, K Futoran, GM Lewitus, D Mukha… - Scientific reports, 2018 - nature.com
Most clinical studies of Cannabis today focus on the contents of two phytocannabinoids:(-)-
Δ9-trans-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), regardless of the fact that …

Cannabis: Chemistry, extraction and therapeutic applications

F Pattnaik, S Nanda, S Mohanty, AK Dalai, V Kumar… - Chemosphere, 2022 - Elsevier
Cannabis, a genus of perennial indigenous plants is well known for its recreational and
medicinal activities. Cannabis and its derivatives have potential therapeutic activities to treat …

Mechanisms of cannabidiol (CBD) in cancer treatment: A review

CG Heider, SA Itenberg, J Rao, H Ma, X Wu - Biology, 2022 - mdpi.com
Simple Summary Emerging evidence suggests positive outcomes from the use of CBD as a
cancer treatment. CBD can relieve cancer pain and ease the side effects of chemotherapy; …

[HTML][HTML] Chemistry, metabolism, and toxicology of cannabis: clinical implications

P Sharma, P Murthy, MMS Bharath - Iranian journal of psychiatry, 2012 - ncbi.nlm.nih.gov
Cannabis is one of the most widely abused substances throughout the world. The primary
psychoactive constituent of cannabis, delta 9-tetrahydrocannabinol (▵ 9_ THC), produces a …

Current aspects of the endocannabinoid system and targeted THC and CBD phytocannabinoids as potential therapeutics for Parkinson's and Alzheimer's diseases: a …

R Cooray, V Gupta, C Suphioglu - Molecular neurobiology, 2020 - Springer
Neurodegeneration leading to Parkinson's disease (PD) and Alzheimer's disease (AD) has
become a major health burden globally. Current treatments mainly target controlling …

Cannabidiol—From plant to human body: A promising bioactive molecule with multi-target effects in cancer

B Kis, FC Ifrim, V Buda, S Avram, IZ Pavel… - International journal of …, 2019 - mdpi.com
Cannabis sativa L. is a plant long used for its textile fibers, seed oil, and oleoresin with
medicinal and psychoactive properties. It is the main source of phytocannabinoids, with over …

Blurred boundaries: the therapeutics and politics of medical marijuana

JM Bostwick - Mayo Clinic Proceedings, 2012 - Elsevier
For 5 millennia, Cannabis sativa has been used throughout the world medically,
recreationally, and spiritually. From the mid-19th century to the 1930s, American physicians …