Overexpression of ascitic interleukin-35 induces CD8+ T cell exhaustion in liver cirrhotic patients with spontaneous bacterial peritonitis
L Yang, S Liu, Q Zhang, S Jia, C Qiu, Z Jin - International …, 2022 - Elsevier
Abstract Interleukin (IL)-35 induces immunotolerance by suppression of CD8+ T cells during
chronic infections and cancers. In the present study, we amined to investigate the role of IL …
chronic infections and cancers. In the present study, we amined to investigate the role of IL …
Splenic CD4+ and CD8+ T-cells highly expressed PD-1 and Tim-3 in cirrhotic patients with HCV infection and portal hypertension
N Huang, R Zhou, H Chen, S Zhang… - International …, 2021 - journals.sagepub.com
Introduction: The spleen plays an important role in regulating the immune response to
infectious pathogens. T-cells dysfunction and exhaustion have been reported in patients …
infectious pathogens. T-cells dysfunction and exhaustion have been reported in patients …
Characteristics of CD8+ Stem Cell-Like Memory T Cell Subset in Chronic Hepatitis C Virus Infection
X Lu, B Song, W Weng, B Su, H Wu, AKL Cheung… - Viral …, 2023 - liebertpub.com
The dysfunction of memory CD8+ T cell cannot be reverted by successful clearance of
hepatitis C virus (HCV) after direct-acting antivirals (DAAs) therapy, increasing the risk of …
hepatitis C virus (HCV) after direct-acting antivirals (DAAs) therapy, increasing the risk of …
CD8 T cell hyperfunction and reduced tumour control in models of advanced liver fibrosis
J Madani, J Li, A Vranjkovic, K Jorritsma, MS Hasim… - bioRxiv, 2023 - biorxiv.org
Immune dysfunction, both depression and hyperactivation, in liver disease contributes to
significant morbidities and mortalities, depending on liver damage severity and etiology. The …
significant morbidities and mortalities, depending on liver damage severity and etiology. The …
Cryoglobulinemic vasculitis
Cryoglobulinemic vasculitis is a small-and medium-sized vasculitis characterized by
immune complex deposition in various tissues. Cryoglobulins (CGs) are cold precipitable …
immune complex deposition in various tissues. Cryoglobulins (CGs) are cold precipitable …