Cell migration is crucial for physiological and pathological processes such as
morphogenesis, wound repair, immune response and cancer invasion/metastasis. There are …

Radiation therapy (RT) is a standard treatment for solid tumors and about 50% of patients
with cancer, including pediatric cancer, receive RT. While RT has significantly improved the …

The glycolytic enzyme lactate dehydrogenase A (LDHA) is frequently overexpressed in
cancer, which promotes glycolysis and cancer. The oncogenic effect of LDHA has been …

The 21kD GTPase Rac is an evolutionarily ancient regulator of cell shape and behavior.
Rac2 is predominantly expressed in hematopoietic cells where it is essential for survival and …

Circadian rhythms regulate various processes in the human body, including drug
metabolism. Chronotherapy optimizes treatment timing based on the circadian rhythm of the …

Small molecule inhibitors of GTPases are increasingly considered for the treatment of
multiple human pathologies. The GTPase Rac1 (Ras-related C3 botulinum toxin substrate 1) …

Physiological changes in GTP levels in live cells have never been considered a regulatory
step of RAC1 activation because intracellular GTP concentration (determined by …

This study aims to give a new perspective to the biomarkers in the lung adenocarcinoma
(LUAD) brain metastasis, pathways involved and potential therapeutics. We performed a …

Despite novel targeted and immunotherapies, the prognosis remains bleak for patients with
hepatocellular carcinoma (HCC), especially for advanced and/or metastatic forms. The rapid …

Prolonged obstruction of the ureter, which leads to injury of the kidney collecting ducts,
results in permanent structural damage, while early reversal allows for repair. Cell structure …