Simple Summary The prevention and treatment of cancer is an ongoing medical challenge.
In the context of personalized medicine, the well-studied polyphenol resveratrol could …

Sirtuins are a family of protein deacylases and ADP-ribosyl-transferases, homologs to the
yeast SIR2 protein. Seven sirtuin paralogs have been described in mammals, with different …

Abstract Serine Threonine Tyrosine Kinase 1 (STYK1) presents oncogenic properties in
many studies, and emerging evidence suggests that ferroptosis serve as a novel tumor …

In the long term, diabetes profoundly affects multiple organs, such as the kidney, heart,
brain, liver, and eyes. The gradual loss of function in these vital organs contributes to …

Objectives: Cancer-associated fibroblast (CAF) is among the most important tumor-host
microenvironment components by affecting tumor progression. This study explored the role …

Background Anticancer drugs generate excessive reactive oxygen species (ROS), which
can cause cell death. Cancer cells can resist this oxidative stress, but the mechanism of …

The mammalian sirtuin family consists of seven proteins, three of which (SIRT3, SIRT4, and
SIRT5) localise specifically within mitochondria and preserve mitochondrial function and …

Lung cancer is the leading cause of cancer death worldwide. Cigarette smoking is the most
common risk factor for lung carcinoma; other risks include genetic factors and exposure to …

Objective: Radiotherapy is an indispensable approach for lung cancer, especially for non-
small cell lung cancer (NSCLC) with high incidence and mortality. However, cellular …

Circular RNAs have been identified as diagnostic and therapeutic targets for various tumors.
The expression of circ_rac GTPase–activating protein 1 (circRACGAP1) is reported to drive …