Ischemic stroke is a highly complex and devastating neurological disease. The sudden loss
of blood flow to a brain region due to an ischemic insult leads to severe damage to that area …

Seizures often herald the clinical appearance of gliomas or appear at later stages.
Dissecting their precise evolution and cellular pathogenesis in brain malignancies could …

Background: Delayed cerebral ischemia (DCI) is a common and serious complication of
aneurysmal subarachnoid hemorrhage (aSAH). Though many clinical trials have looked at …

Objective Spreading depolarizations (SD) are characterized by breakdown of
transmembrane ion gradients and excitotoxicity. Experimentally, N-methyl-d-aspartate …

Stroke poses a serious threat to human health and burdens both society and the healthcare
system. Standard rehabilitative therapies may not be effective in improving functions after …

Simple Summary A stroke occurs when there is a lack of blood flow to the brain. Stroke
injures the brain and can have devastating outcomes depending on the size and location of …

Neuronal swelling during cytotoxic edema is triggered by Na+ and Cl− entry and is Ca 2+
independent. However, the causes of neuronal death during swelling are unknown. Here …

Background and Purpose: Ischemic injury triggers multiple pathological responses in the
brain tissue, including spreading depolarizations across the cerebral cortex (cortical …

Spreading depolarization is observed as a large negative shift of the direct current potential,
swelling of neuronal somas, and dendritic beading in the brain's gray matter and represents …

Background Recent discovery of mechanosensitive Piezo receptors in trigeminal ganglia
suggested the novel molecular candidate for generation of migraine pain. However, the …