The understanding of deposition of particles in the respiratory tract is of great value to risk
assessment of inhalation toxicology and to improve efficiency in drug delivery of inhalation …

The efficacy of pharmaceutical aerosols relates to its deposition in the clinically relevant
regions of the lungs, which can be assessed by in vivo lung deposition studies. Dry powder …

This thoroughly revised and expanded reference provides authoritative discussions on the
physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors …

Over recent years the research focus within the field of respiratory drug delivery has
broadened to include a wide range of potential applications for inhalation by delivering …

Introduction Drugs for the treatment of respiratory diseases are commonly administered by
oral inhalation. Yet surprisingly little is known about the pulmonary pharmacokinetics of …

Positron Emission Tomography is a high-resolution, sensitive, functional imaging technique,
which can efficiently give access to the distribution, pharmacokinetics and-dynamics of a …

This article is part of a series of reports from the “Orlando Inhalation Conference-Approaches
in International Regulation” which was held in March 2014, and coorganized by the …

Quantification of target site pharmacokinetics (PK) is crucial for drug discovery and
development. Clinical micro-dialysis (MD) has increasingly been employed for the …

Purpose In the present work, a comparison between MDI and DPI for evaluating
performance of the devices were carried out by experimentally investigating the deposition …

Whole lung and regional lung deposition of inhaled asthma drugs in the lungs can be
quantified using either two-dimensional or three-dimensional radionuclide imaging …