Abstract Cyclobutane pyrimidine dimers and (6–4) photoproducts are the two major classes
of lesions produced in DNA by UVB and UVC irradiation. Their distribution along genes is …

When populations of microorganisms are subjected to certain nonlethal selections, useful
mutants arise among the nongrowing cells whereas useless mutants do not. This …

Lesions in the transcribed strand block transcription and are repaired more rapidly than
lesions in the nontranscribed (coding) strand which do not block RNA polymerase (RNAP). It …

To identify the sites in the p53 tumor suppressor gene most susceptible to carcinogenic
mutation by sunlight, the entire coding region of 27 basal cell carcinomas (BCCs) of the skin …

In 1994 we described a list of∼ 2500 point mutations in the p53 gene of human tumors and
cell lines which we had compiled from the published literature and made available …

If the genome contains outlier sequences extraordinarily sensitive to environmental agents,
these would be sentinels for monitoring personal carcinogen exposure and might drive …

Transcription-coupled repair (TCR) is a sub-pathway of nucleotide excision repair (NER)
that preferentially removes lesions from the template-strand (t-strand) that stall RNA …

Nucleotide excision repair is a versatile mechanism to repair a variety of bulky DNA adducts.
We developed excision repair sequencing (XR-seq) to study nucleotide excision repair of …

Mutation frequency decline is the rapid and irreversible decline in the suppressor mutation
frequency of Escherichia coli cells if the cells are kept in nongrowth media immediately …

On UV irradiation of Escherichia coli cells, DNA replication is transiently arrested to allow
removal of DNA damage by DNA repair mechanisms. This is followed by a resumption of …