Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues
Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed
from a research tool to a clinical application for the diagnosis and management of …
from a research tool to a clinical application for the diagnosis and management of …
[HTML][HTML] Molecular diagnosis of drug-resistant tuberculosis; a literature review
Drug-resistant tuberculosis is a global health problem that hinders the progress of
tuberculosis eradication programs. Accurate and early detection of drug-resistant …
tuberculosis eradication programs. Accurate and early detection of drug-resistant …
A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis
P Miotto, B Tessema, E Tagliani… - European …, 2017 - Eur Respiratory Soc
A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium
tuberculosis is required to accelerate the development of rapid drug susceptibility testing …
tuberculosis is required to accelerate the development of rapid drug susceptibility testing …
Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
To characterize the genetic determinants of resistance to antituberculosis drugs, we
performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis …
performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis …
[HTML][HTML] Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs
Background Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major
threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction …
threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction …
[HTML][HTML] Genetic sequencing for surveillance of drug resistance in tuberculosis in highly endemic countries: a multi-country population-based surveillance study
Background In many countries, regular monitoring of the emergence of resistance to anti-
tuberculosis drugs is hampered by the limitations of phenotypic testing for drug …
tuberculosis drugs is hampered by the limitations of phenotypic testing for drug …
[HTML][HTML] Epidemiological cut-off values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing of M. tuberculosis
CRyPTIC Consortium - European Respiratory Journal, 2022 - Eur Respiratory Soc
Drug susceptibility testing of M. tuberculosis is rooted in a binary susceptible/resistant
paradigm. While there are considerable advantages in measuring the minimum inhibitory …
paradigm. While there are considerable advantages in measuring the minimum inhibitory …
[HTML][HTML] Mycobacterium tuberculosis resistance prediction and lineage classification from genome sequencing: comparison of automated analysis tools
Whole-genome sequencing (WGS) has the potential to accelerate drug-susceptibility testing
(DST) to design appropriate regimens for drug-resistant tuberculosis (TB). Several recently …
(DST) to design appropriate regimens for drug-resistant tuberculosis (TB). Several recently …
[HTML][HTML] Artificial intelligence and cardiovascular genetics
Polygenic diseases, which are genetic disorders caused by the combined action of multiple
genes, pose unique and significant challenges for the diagnosis and management of …
genes, pose unique and significant challenges for the diagnosis and management of …
Advances in the molecular diagnosis of tuberculosis: from probes to genomes
Tuberculosis, disease caused by Mycobacterium tuberculosis, is currently the leading cause
of death by a single infectious agent worldwide. Early, rapid and accurate identification of M …
of death by a single infectious agent worldwide. Early, rapid and accurate identification of M …