Accumulating evidence suggests that colorectal cancer (CRC) should be viewed as a
heterogeneous disease, with proximal and distal CRCs showing multiple biological and …

Colorectal cancer (CRC) is a common health problem, representing the third most
commonly diagnosed cancer worldwide and causing a significant burden in terms of …

BACKGROUND & AIMS: There is evidence that serrated polyps (serrated adenomas and
hyperplastic polyps) have different malignant potential than traditional adenomas. We used …

There is now strong evidence for an alternative pathway of colorectal carcinogenesis
implicating hyperplastic polyps and serrated adenomas. This article briefly reviews the …

Purpose: The issue of whether colon and rectal cancer should be considered as a single
entity or two distinct entities is still debated, and there is a need to improve studies …

Aims: To characterize a series of colorectal polyps, focusing on the clinicopathological
features of serrated adenoma (SA), mixed polyp (MP) and the recently recognized sessile …

Aim: To establish and explain the pattern of molecular signatures across colorectal polyps.
Methods and results: Thirty‐two sessile serrated adenomas (SSA), 10 mixed polyps (MP), 15 …

Colonic cancers with a serrated morphology have been proposed to comprise a molecularly
distinct tumor entity following an alternative pathway of genetic alterations independently of …

Colorectal cancer is a worldwide problem having global increases in the number of cases
and deaths because of the expanding and aging of the population in both developing and …

In intestinal epithelial cells, inactivation of APC, a key regulator of the Wnt pathway, activates
β-catenin to initiate tumorigenesis. However, other alterations may be involved in intestinal …