We investigated the frequency of promoter region CpG island methylation (CIM) of hMLH1,
MGMT, MINT1, MINT2, and p16 INK4a and K-ras mutations in a total of 79 hyperplastic …

It is well known that adenomas represent the morphologically categorised precursor of the
vast majority of colorectal cancers. Only few adenomas actually develop invasive cancer …

To clarify distinct genetic profiles of colorectal cancers based on tumor location (left-and right-
sided), we evaluated the status of loss of heterozygosity (LOH), CpG islands methylation …

DNA copy number changes represent molecular fingerprints of solid tumors and are as such
relevant for better understanding of tumor development and progression. In this study, we …

Although epidemiological studies indicate an association between elevations in fecal bile
acids and the development of colorectal cancer, the cellular mechanism for the proliferative …

OBJECTIVES: Serrated polyps of the colorectum are a histologically and genetically
heterogeneous group of lesions, which include classic hyperplasic polyps, sessile serrated …

Advances in our understanding of the molecular basis of colorectal cancer (CRC) have shed
new light on the nature of hyperplastic polyps and invite a reassessment of the relevance of …

Colorectal serrated adenocarcinoma originates from serrated adenoma, but definite
histological criteria have not yet been established. It presents with frequent DNA …

Until recently, two major types of colorectal epithelial polyps were distinguished: the
adenoma and the hyperplastic polyp. While adenomas—because of their cytological atypia …

Patients with ulcerative colitis (UC) are at an increased risk for the development of colorectal
cancer (CRC). Unlike sporadic CRC, the cancer in UC patients arises from a focal or …