Patients with ulcerative colitis (UC) are at an increased risk for the development of colorectal
cancer (CRC). Unlike sporadic CRC, the cancer in UC patients arises from a focal or …

There are two major molecular pathways to sporadic colorectal cancer, the chromosomal
instability (CIN) and the CpG island methylator phenotype (CIMP) pathways. This study …

Background: Hyperplastic polyposis of the colorectum is a precancerous condition that has
been linked with DNA methylation. The polyps in this condition have been distinguished …

Raf-1 kinase inhibitor protein (RKIP) is known as a critical down-regulator of the mitogen-
activated protein kinase signaling pathway and a potential molecular determinant of …

Mutated in colorectal cancer (MCC) was originally identified as a candidate gene for familial
adenomatous polyposis (FAP) but further study identified adenomatous polyposis coli (APC) …

A subset of colorectal cancers with CpG island methylator phenotype‐high (CIMP‐H) is
frequently associated with MSI and BRAF V600E mutation. Since limited data are available …

It was a century ago that Warthin, a pathologist, first described the clinical condition now
known as Lynch syndrome. One hundred years later, our understanding of this syndrome …

The majority of colon cancers develop from pre-existing adenomas. We analyzed the
expression profiles in the sequence of normal colon crypts, adenomas and early-stage …

Background & Aims: Colorectal cancers (CRCs) with the CpG island methylator phenotype
(CIMP) often associate with epigenetic silencing of hMLH1 and an activating mutation in the …

ABSTRACT β-catenin has two distinct functions, namely, maintaining cell-to-cell adhesion
and mediating the Wnt/β-catenin signal transduction pathway, which plays pivotal roles in …