The majority of colon cancers develop from pre-existing adenomas. We analyzed the
expression profiles in the sequence of normal colon crypts, adenomas and early-stage …

Background & Aims: Identification of preneoplastic changes in histologically normal
epithelium (the “field effect”) could provide a powerful screening tool for colorectal cancer …

ABSTRACT β-catenin has two distinct functions, namely, maintaining cell-to-cell adhesion
and mediating the Wnt/β-catenin signal transduction pathway, which plays pivotal roles in …

Background & Aims: Colorectal cancers (CRCs) with the CpG island methylator phenotype
(CIMP) often associate with epigenetic silencing of hMLH1 and an activating mutation in the …

Background: Mismatch repair-deficient (dMMR) colorectal cancer (CRC) is associated with a
conspicuous local immune infiltrate; however, its relationship with systemic inflammatory …

Since the third edition of this book, the rapid development in our understanding of inherited
cancer susceptibility has continued apace. This edition is the first to be published by …

Colorectal mucosa is targeted by toxic agents, which can initiate or promote colon cancer.
The mechanism of damage might be a focal irritation with loss of normal epithelial cell …

Colorectal cancer arises as a result of the accumulation of genetic errors many of which
affect the control of apoptosis. Effective chemoprevention strategies for colorectal cancer …

Purpose: Irinotecan is used in the first-line treatment of metastatic colorectal cancer. The
UGT1A1-metabolizing enzyme, expressed in liver and colon, is primarily involved in the …

Colorectal cancer (CRC) is the second leading cause of cancer deaths in USA. Anti-
inflammatory drugs were shown to be effective in the prevention of CRC, supporting a link …