The human MAS-related G protein–coupled receptor X1 (MRGPRX1) is preferentially
expressed in the small-diameter primary sensory neurons and involved in the mediation of …

Several neurochemical systems converge in the prefrontal cortex (PFC) to regulate cognitive
and motivated behaviors. A rich network of endogenous opioid peptides and receptors …

This paper is the forty-fourth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Although largely confined to the airways, SARS-CoV-2 infection has been associated with
sensory abnormalities that manifest in both acute and chronic phenotypes. To gain insight …

The peptide hormone angiotensin II regulates blood pressure mainly through the type 1
angiotensin II receptor AT1R and its downstream signaling proteins Gq and β‐arrestin …

Abstract Opioid Use Disorder (OUD) can be described as intense preoccupation with using
or obtaining opioids despite the negative consequences associated with their use. As the …

G protein-coupled receptors (GPCRs) are the most highly targeted protein family by United
States Food and Drug Administration-approved drugs. Despite their historic and continued …

Gastrointestinal motility is tightly regulated by the enteric nervous system (ENS). Disruption
of coordinated enteric nervous system activity can result in dysmotility. Pharmacological …

TRUPATH is a bioluminescence resonance energy transfer-based platform for quantifying G
protein-coupled receptor activity via dissociation of heterotrimeric G protein biosensors …

Chronic pain is a prevalent and persistent ailment that affects individuals worldwide.
Conventional medications employed in the treatment of chronic pain typically demonstrate …