[HTML][HTML] Tumor Microenvironment Modulation by Cancer-Derived Extracellular Vesicles

A Ten, V Kumeiko, V Farniev, H Gao, M Shevtsov - Cells, 2024 - mdpi.com
The tumor microenvironment (TME) plays an important role in the process of tumorigenesis,
regulating the growth, metabolism, proliferation, and invasion of cancer cells, as well as …

[HTML][HTML] Covalent conjugation of AZD8055 with unsaturated fatty acids for the development of mTOR nanoblockers: increasing the therapeutic efficacy of …

WK Chau, TKW Lee - Ebiomedicine, 2024 - thelancet.com
In the latest issue of eBioMedicine, Tang et al. utilized a nanotherapeutic approach to
specifically target the mTOR pathway by PEGylating linoleic acid (LNA)-conjugated …

Mapping Heterogeneity of Hepatocellular Carcinoma by Investigating Hepatocyte-Specific Genes/TFs/Pathways Across Cellular and Tumor Landscapes

O Shafi, R Rajpar, S Zafar, S Irfan, M Ashar, SH Jafry… - 2024 - researchsquare.com
Background: Hepatocellular carcinoma (HCC) presents challenges due to tumor
heterogeneity and therapeutic resistance. Understanding the molecular mechanisms driving …