The role of novel biomarker HE4 in the diagnosis, prognosis and follow-up of ovarian cancer: a systematic review

G Scaletta, F Plotti, D Luvero… - Expert review of …, 2017 - Taylor & Francis
Introduction: Ovarian cancer is the leading cause of death from gynecologic cancers, in
fact,> 80% of cases are diagnosed as advanced-stage disease associated with a high …

The potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer

M Widschwendter, M Zikan, B Wahl, H Lempiäinen… - Genome Medicine, 2017 - Springer
Background Despite a myriad of attempts in the last three decades to diagnose ovarian
cancer (OC) earlier, this clinical aim still remains a significant challenge. Aberrant …

Prognostic value of serum and tissue HE4 expression in ovarian cancer: a systematic review with meta-analysis of 90 studies

H Cao, D You, Z Lan, H Ye, M Hou… - Expert review of molecular …, 2018 - Taylor & Francis
Introduction: Ovarian cancer (OC) is one of the leading causes of cancer-related death in
women. Accumulating evidence showed an evolving role of HE4 in monitoring the …

HE4 promotes collateral resistance to cisplatin and paclitaxel in ovarian cancer cells

JR Ribeiro, C Schorl, N Yano, N Romano… - Journal of Ovarian …, 2016 - Springer
Background Chemotherapy resistance presents a difficult challenge in treating epithelial
ovarian cancer patients, particularly when tumors exhibit resistance to multiple …

Early clearance of serum HE4 and CA125 in predicting platinum sensitivity and prognosis in epithelial ovarian cancer

Y Rong, L Li - Journal of ovarian research, 2021 - Springer
Objectives To assess the clinical value of early clearance of HE4 and CA125 for platinum
sensitivity and prognosis in patients with ovarian cancer. Method HE4 and CA125 value …

[HTML][HTML] Overexpression of HE4 (human epididymis protein 4) enhances proliferation, invasion and metastasis of ovarian cancer

L Zhu, H Zhuang, H Wang, M Tan, CL Schwab… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Overexpression of Human epididymis protein 4 (HE4) related with a role in ovarian cancer
tumorigenesis while little is known about the molecular mechanism alteration by HE4 up …

Role of human epididymis protein 4 in chemoresistance and prognosis of epithelial ovarian cancer

S Lee, S Choi, Y Lee, D Chung… - Journal of Obstetrics …, 2017 - Wiley Online Library
Aim Human epididymis protein 4 (HE4) is a novel biomarker for epithelial ovarian cancer.
This study was designed to evaluate the role of HE4 in chemo‐response against anti‐cancer …

Serum HE4 superior to CA125 in predicting poorer surgical outcome of epithelial ovarian cancer

Y Shen, L Li - Tumor Biology, 2016 - Springer
Epithelial ovarian cancer (EOC) remains the deadliest form of gynecological cancers.
Optimal tumor debulking, no matter the primary or the interval, is the most important …

18F-FDG-PET/CT based total metabolic tumor volume change during neoadjuvant chemotherapy predicts outcome in advanced epithelial ovarian cancer

T Vallius, J Hynninen, J Kemppainen, V Alves… - European journal of …, 2018 - Springer
Objective To evaluate the predictive potential of total metabolic tumor volume (MTV)
reduction during neoadjuvant chemotherapy (NACT) with 18 F–FDG-PET/CT in an …

18F-FDG-PET/CT can identify histopathological non-responders to platinum-based neoadjuvant chemotherapy in advanced epithelial ovarian cancer

T Vallius, A Peter, A Auranen, O Carpén… - Gynecologic …, 2016 - Elsevier
Objective The aim of this study was to examine the relationship between the reduction of
maximum standardized uptake values (SUVmax) in 18 F-FDG-PET/CT to histopathological …