Antibiotic treatment of tuberculosis has a duration of several months. There is significant
variability of the host immune response and the pharmacokinetic-pharmacodynamic …

Background/Aims. Nucleotide diversity may affect the immune regulation of tuberculosis (TB)
patients, leading to the individual susceptibility to TB. In recent years, there are a lot of …

Abstract Pattern Recognition Receptors (PRRs) play a central role in the recognition of
numerous pathogens, including Mycobacterium tuberculosis, resulting in activation of innate …

Tuberculosis (TB) is a chronic and fatal zoonotic infectious disease caused by
Mycobacterium tuberculosis (M. tb) infection. The THP‑1 cell line is a cell model for studying …

Centuries since it was first described, tuberculosis (TB) remains a significant global public
health issue. Despite ongoing holistic measures implemented by health authorities and a …

Susceptibility to tuberculosis and progression of the disease depend on interactions
between the bacterial agent, host immune system, and environmental and genetic factors. In …

Nuclear receptors (NRs) are ligand-activated transcription factors that are expressed in a
wide variety of cells and play a major role in lipid signaling. NRs are key regulators of …

Tuberculosis (TB) poses an important health challenge and a significant economic burden
for Kazakhstan and in Central Asia. Recent findings show a number of immunological …

The skin tuberculin test (TST), an example of a delayed-type hypersensitivity (DTH) reaction,
is based on measuring the extent of skin induration to mycobacterial tuberculin (PPD). Little …

The PPE (proline-proline-glutamic acid) proteins of Mycobacterium tuberculosis are
characterized by a conserved N-terminal domain of approximately 180 amino acids and …