Chronic obstructive pulmonary disease (COPD) represents a socio-economic burden and
requires regular and ongoing treatment. Inhalation therapy is recommended at all stages of …

Background Preserved ratio impaired spirometry (PRISm) is defined as a FEV 1 of less than
80% predicted and a FEV 1/forced vital capacity (FVC) ratio of 0· 70 or higher. Previous …

For more than 50 years, small airways disease has been considered a key feature of chronic
obstructive pulmonary disease (COPD) and a major cause of airway obstruction. Both …

Background Severe inflammatory airway diseases are associated with inflammation that
does not resolve, leading to structural changes and an overall environment primed for …

Supplemental O2 (hyperoxia; 30–90% O2) is a necessary intervention for premature infants,
but it contributes to development of neonatal and pediatric asthma, necessitating better …

Allergic asthma is a common chronic inflammation of the airways and causes airway
remodeling eventually. For a long time, investigators have been focusing on the …

Evidence that enables us to identify, assess, and access the small airways in asthma and
chronic obstructive pulmonary disease (COPD) has led INTERASMA (Global Asthma …

Evidence of the respiratory effects of ambient organic aerosols (eg, polycyclic aromatic
hydrocarbons, PAHs) among patients with chronic diseases is limited. We aimed to assess …

Introduction There is a clear correlation between small airways dysfunction and poor clinical
outcomes in patients with chronic obstructive pulmonary disease (COPD), and it is therefore …

COPD and asthma have different risk factors and pathogenesis, but they share a
pathophysiologic hallmark characterized by small airways disease. Although difficult to …