Publisher Summary This chapter deals with the structure and function of the leader transcript
of human immunodeficiency virus (HIV-1) and HIV-2. Most of the RNA signals encoded by …

Depending on the stage of their intervention with the viral replicative cycle, human
immunodeficiency virus inhibitors could be divided into the following groups:(i) adsorption …

Effective intracellular expression of small RNA therapeutics depends on a number of factors.
The RNA, whether antisense, ribozyme, or RNA aptamer, must be efficiently transcribed …

Modified oligonucleotides 3'-NHP (O)(O) O-5'phosphora midates were synthesized on a
solid phase Support. The phosphoramidate analogs were found to have significantly …

Abstract Modified oligonucleotides 3′-NHP (O)(O−) O-5′ phosphoramidates were
synthesized on a solid phase support. The phosphoramidate analogs were found to have …

The polymerase (PB2) and nucleocapsid (NP) genes encoded by the genome of influenza
virus are essential for replication of the virus. When synthetic genes that express RNAs for …

Gene therapy is being investigated as an alternative treatment for a wide range of infectious
diseases that are not amenable to standard clinical management. Approaches to gene …

Abstract Modified oligodeoxyribonucleotide 3'--NHP (O)(O-) O-5'phosphoramidates were
synthesized on a solid phase support. The phosphoramidate analogs were found to have …

[57] ABSTRACT Modi? ed oligonucleotides 3'-NHP (O)(O_) O-5'phosphora midates were
synthesized on a solid phase support. The phosphoramidate analogs were found to have …

Dysregulation of cytokines secreted by T cells may play an important role in the
pathogenesis of AIDS. To investigate the effects of human immunodeficiency virus type 1 …