Cancer is the second leading cause of death in the US. Current major treatments for cancer
management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy …

Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

Abstract Background: Idiopathic Pulmonary Fibrosis (IPF) is a progressive inflammatory
disorder driven by a fibrotic cascade of events such as epithelial to mesenchymal transition …

Cancer is a daunting global problem confronting the world's population. The most frequent
therapeutic approaches include surgery, chemotherapy, radiotherapy, and more recently …

Conventional chemotherapy, one of the most widely used cancer treatment methods, has
serious side effects, and usually results in cancer treatment failure. Drug resistance is one of …

ATP-binding cassette (ABC) transporters are membrane-spanning proteins involved in
cholesterol homeostasis, transport of various molecules in and out of cells and organelles …

Drug delivery into the brain is regulated by the blood–brain interfaces. The blood–brain
barrier (BBB), the blood–cerebrospinal fluid barrier (BCSFB), and the blood–arachnoid …

Triple-negative breast cancer (TNBC) is one of the most lethal forms of breast cancer (BC),
with a significant disease burden worldwide. Chemoresistance and lack of targeted …