Oxidative stress, inflammation, mitochondrial dysfunction, reduced protein synthesis, and
increased proteolysis are all critical factors in the process of muscle atrophy. In particular …

Westernized populations are plagued by a plethora of chronic non-infectious degenerative
diseases, termed as “civilization diseases”, like obesity, diabetes, cardiovascular diseases …

Skeletal muscle atrophy is prevalent in a myriad of pathological conditions, such as
diabetes, denervation, long-term immobility, malnutrition, sarcopenia, obesity, Alzheimer's …

Background: The concept of sarcopenic obesity refers to low muscle mass coupled with high
adiposity in older adults. Sarcopenic obesity is a new medical challenge that imposes …

Obesity causes progressive lipid accumulation and insulin resistance within muscle cells
and affects skeletal muscle fibres and muscle mass that demonstrates atrophy and …

Background Chinese yam polysaccharide (CYP), a bioactive compound of Chinese yam,
has been proven to exhibit many pharmacological effects, such as anti-inflammatory, anti …

Heart failure and cardiovascular disorders represent the leading cause of death in diabetic
patients. Here we present a systematic review of the main mechanisms underlying the …

Obesity is a highly prevalent disease that can induce metabolic syndrome and is associated
with a greater risk of muscular atrophy. Mitochondria play central roles in regulating the …

This study investigated the role of diacylglycerol (DAG)‐mediated protein kinase C (PKC)
activation, ceramide accumulation and inflammation in insulin‐resistant female oxidative …

Animal experimentation has a long history in the study of metabolic syndrome-related
disorders. However, no consensus exists on the best models to study these syndromes …