Microfluidic tissue engineering and bio‐actuation

M Filippi, T Buchner, O Yasa, S Weirich… - Advanced …, 2022 - Wiley Online Library
Bio‐hybrid technologies aim to replicate the unique capabilities of biological systems that
could surpass advanced artificial technologies. Soft bio‐hybrid robots consist of synthetic …

3D skin models along with skin-on-a-chip systems: A critical review

W Sun, Z Liu, J Xu, Y Cheng, R Yin, L Ma, H Li… - Chinese Chemical …, 2023 - Elsevier
Skin is the largest organ in human body, and it plays an important role in regulating
physiological microenvironments and acts as a barrier to protect human body from harmful …

Design of hydrogel-based scaffolds for in vitro three-dimensional human skin model reconstruction

SH Tan, DAC Chua, JRJ Tang, C Bonnard… - Acta Biomaterialia, 2022 - Elsevier
In vitro three-dimensional (3D) skin tissue models are critical tools in advancing our
understanding of basic skin physiology and function as well as in specific applications such …

[HTML][HTML] Skin-on-a-chip technology: microengineering physiologically relevant in vitro skin models

P Zoio, A Oliva - Pharmaceutics, 2022 - mdpi.com
The increased demand for physiologically relevant in vitro human skin models for testing
pharmaceutical drugs has led to significant advancements in skin engineering. One of the …

Hierarchical vessel network-supported tumor model-on-a-chip constructed by induced spontaneous anastomosis

Y Zhou, Y Wu, R Paul, X Qin, Y Liu - ACS applied materials & …, 2023 - ACS Publications
The vascular system in living tissues is a highly organized system that consists of vessels
with various diameters for nutrient delivery and waste transport. In recent years, many vessel …

[HTML][HTML] Dynamic flow enables long‐term maintenance of 3‐D vascularized human skin models

R Rimal, Y Marquardt, T Nevolianis, S Djeljadini… - Applied Materials …, 2021 - Elsevier
Approaches to develop three-dimensional (3-D) vascularized human skin equivalents
(vHSEs) that can mimic native skin are currently gaining momentum. Yet, the reproducible …

3D Bioprinted Human Skin Model Recapitulating Native‐Like Tissue Maturation and Immunocompetence as an Advanced Platform for Skin Sensitization Assessment

B Bhar, E Das, K Manikumar… - Advanced Healthcare …, 2024 - Wiley Online Library
Physiologically‐relevant in vitro skin models hold the utmost importance for efficacy
assessments of pharmaceutical and cosmeceutical formulations, offering valuable …

[HTML][HTML] Capillary-like formations of endothelial cells in defined patterns generated by laser bioprinting

L Koch, A Deiwick, B Chichkov - Micromachines, 2021 - mdpi.com
Bioprinting is seen as a promising technique for tissue engineering, with hopes of one day
being able to produce whole organs. However, thick tissue requires a functional vascular …

Recent advances in in vitro skin-on-a-chip models for drug testing

JH Sung, JJ Kim - Expert Opinion on Drug Metabolism & …, 2023 - Taylor & Francis
Introduction The skin is an organ that has the largest surface area and provides a barrier
against external environment. While providing protection, it also interacts with other organs …

[HTML][HTML] New ex vivo method to objectively assess insulin spatial subcutaneous dispersion through time during pump basal-rate based administration

P Jacquemier, Y Retory, C Virbel-Fleischman… - Scientific Reports, 2023 - nature.com
Glycemic variability remains frequent in patients with type 1 diabetes treated with insulin
pumps. Heterogeneous spreads of insulin infused by pump in the subcutaneous (SC) tissue …