Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted
into immunocompromised or humanized mice, have shown superiority in recapitulating the …

After cardiovascular disease, cancer is the leading cause of death worldwide with
devastating health and economic consequences, particularly in developing countries. Inter …

Precision oncology presumes an accurate prediction of drug response on the basis of the
molecular profile of tumors. However, the extent to which patient-derived tumor organoids …

Colorectal cancer (CRC) progression is a complex process that is not well understood. We
describe an in vitro organ-on-chip model that emulates in vivo tissue structure and the tumor …

Introduction Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive and has poor
prognosis. There are few biomarkers to inform treatment decisions, and collecting tumour …

In the US alone, around 60,000 lives/year are lost to colon cancer. In order to study the
mechanisms of colon carcinogenesis, in vitro model systems are required in addition to in …

Simple Summary In its early stages, colorectal cancer (CRC) is a localized tumor, but when it
metastasizes, it has dramatic consequences. Murine models in CRC research are important …

Colorectal cancer is a major public health problem. Unfortunately, currently, no effective
curative option exists for this type of malignancy. The most promising cancer treatment …

Background We propose a new approach for designing personalized treatment for
colorectal cancer (CRC) patients, by combining ex vivo organoid efficacy testing with …

The current standard of care for colorectal cancer (CRC) is a combination of
chemotherapeutics, often supplemented with targeted biological drugs. An urgent need …