Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …

The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …

Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1,
Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the …

Progress in preventing atherosclerotic coronary artery disease (CAD) has been stalled by
the epidemic of type 2 diabetes. Further advances in this area demand a thorough …

Cardiovascular disease (CVD) has become the leading cause of morbidity and mortality
worldwide. A well-monitored diet with a sufficient intake of fruits and vegetables has been …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Background: Although sex differences in coronary artery disease are widely accepted with
women developing more stable atherosclerosis than men, the underlying pathobiology of …

Rationale: The high morbidity/mortality of atherosclerosis is typically precipitated by plaque
rupture and consequent thrombosis. However, research on underlying mechanisms and …

Background: Cross-talk between sterol metabolism and inflammatory pathways has been
demonstrated to significantly affect the development of atherosclerosis. Cholesterol …

Atherosclerosis is a disease of ageing in that its incidence and prevalence increase with
age. However, atherosclerosis is also associated with biological ageing, manifest by a …